Subclone-specific microenvironmental impact and drug response in refractory multiple myeloma revealed by single‐cell transcriptomics

Stephan M. Tirier, Jan-Philipp Mallm, Simon Steiger, Alexandra M. Poos, Mohamed H. S. Awwad, Nicola Giesen, Nicola Casiraghi, Hana Susak, Katharina Bauer, Anja Baumann, Lukas John, Anja Seckinger, Dirk Hose, Carsten Müller-Tidow, Hartmut Goldschmidt, Oliver Stegle, Michael Hundemer, Niels Weinhold, Marc S. Raab () and Karsten Rippe ()
Additional contact information
Stephan M. Tirier: Division of Chromatin Networks, German Cancer Research Center (DKFZ) and Bioquant
Jan-Philipp Mallm: Division of Chromatin Networks, German Cancer Research Center (DKFZ) and Bioquant
Simon Steiger: Division of Chromatin Networks, German Cancer Research Center (DKFZ) and Bioquant
Alexandra M. Poos: University Hospital Heidelberg, Internal Medicine V
Mohamed H. S. Awwad: University Hospital Heidelberg, Internal Medicine V
Nicola Giesen: University Hospital Heidelberg, Internal Medicine V
Nicola Casiraghi: Division of Computational Genomics and System Genetics, German Cancer Research Center (DKFZ)
Hana Susak: Division of Computational Genomics and System Genetics, German Cancer Research Center (DKFZ)
Katharina Bauer: Single Cell Open Lab, German Cancer Research Center (DKFZ) and Bioquant
Anja Baumann: CCU Molecular Hematology/Oncology, German Cancer Research Center (DKFZ)
Lukas John: University Hospital Heidelberg, Internal Medicine V
Anja Seckinger: University Hospital Heidelberg, Internal Medicine V
Dirk Hose: University Hospital Heidelberg, Internal Medicine V
Carsten Müller-Tidow: University Hospital Heidelberg, Internal Medicine V
Hartmut Goldschmidt: University Hospital Heidelberg, Internal Medicine V
Oliver Stegle: Division of Computational Genomics and System Genetics, German Cancer Research Center (DKFZ)
Michael Hundemer: University Hospital Heidelberg, Internal Medicine V
Niels Weinhold: University Hospital Heidelberg, Internal Medicine V
Marc S. Raab: University Hospital Heidelberg, Internal Medicine V
Karsten Rippe: Division of Chromatin Networks, German Cancer Research Center (DKFZ) and Bioquant

Nature Communications, 2021, vol. 12, issue 1, 1-16

Abstract: Relapsed/refractory multiple myeloma (RRMM) is characterized by a remarkable heterogeneity and high drug resistance. Here, the authors analyse RRMM samples by single-cell RNA-sequencing, revealing molecular features associated with high-risk chromosomal 1q-gain and changes in the tumor microenvironment.

Date: 2021
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DOI: 10.1038/s41467-021-26951-z

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