The main oxidative inactivation pathway of the plant hormone auxin

Ken-ichiro Hayashi (), Kazushi Arai, Yuki Aoi, Yuka Tanaka, Hayao Hira, Ruipan Guo, Yun Hu, Chennan Ge, Yunde Zhao, Hiroyuki Kasahara and Kosuke Fukui
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Ken-ichiro Hayashi: Okayama University of Science
Kazushi Arai: Okayama University of Science
Yuki Aoi: United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology
Yuka Tanaka: Okayama University of Science
Hayao Hira: Graduate School of Agriculture, Tokyo University of Agriculture and Technology
Ruipan Guo: Section of Cell and Developmental Biology, University of California San Diego
Yun Hu: Section of Cell and Developmental Biology, University of California San Diego
Chennan Ge: Section of Cell and Developmental Biology, University of California San Diego
Yunde Zhao: Section of Cell and Developmental Biology, University of California San Diego
Hiroyuki Kasahara: Graduate School of Agriculture, Tokyo University of Agriculture and Technology
Kosuke Fukui: Okayama University of Science

Nature Communications, 2021, vol. 12, issue 1, 1-11

Abstract: Abstract Inactivation of the phytohormone auxin plays important roles in plant development, and several enzymes have been implicated in auxin inactivation. In this study, we show that the predominant natural auxin, indole-3-acetic acid (IAA), is mainly inactivated via the GH3-ILR1-DAO pathway. IAA is first converted to IAA-amino acid conjugates by GH3 IAA-amidosynthetases. The IAA-amino acid conjugates IAA-aspartate (IAA-Asp) and IAA-glutamate (IAA-Glu) are storage forms of IAA and can be converted back to IAA by ILR1/ILL amidohydrolases. We further show that DAO1 dioxygenase irreversibly oxidizes IAA-Asp and IAA-Glu into 2-oxindole-3-acetic acid-aspartate (oxIAA-Asp) and oxIAA-Glu, which are subsequently hydrolyzed by ILR1 to release inactive oxIAA. This work established a complete pathway for the oxidative inactivation of auxin and defines the roles played by auxin homeostasis in plant development.

Date: 2021
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DOI: 10.1038/s41467-021-27020-1

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