Multi-species host range of staphylococcal phages isolated from wastewater

Pauline C. Göller, Tabea Elsener, Dominic Lorgé, Natasa Radulovic, Viona Bernardi, Annika Naumann, Nesrine Amri, Ekaterina Khatchatourova, Felipe Hernandes Coutinho, Martin J. Loessner and Elena Gómez-Sanz ()
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Pauline C. Göller: ETH Zurich
Tabea Elsener: ETH Zurich
Dominic Lorgé: ETH Zurich
Natasa Radulovic: ETH Zurich
Viona Bernardi: ETH Zurich
Annika Naumann: ETH Zurich
Nesrine Amri: ETH Zurich
Ekaterina Khatchatourova: ETH Zurich
Felipe Hernandes Coutinho: Universidad Miguel Hernández
Martin J. Loessner: ETH Zurich
Elena Gómez-Sanz: ETH Zurich

Nature Communications, 2021, vol. 12, issue 1, 1-17

Abstract: Abstract The host range of bacteriophages defines their impact on bacterial communities and genome diversity. Here, we characterize 94 novel staphylococcal phages from wastewater and establish their host range on a diversified panel of 117 staphylococci from 29 species. Using this high-resolution phage-bacteria interaction matrix, we unveil a multi-species host range as a dominant trait of the isolated staphylococcal phages. Phage genome sequencing shows this pattern to prevail irrespective of taxonomy. Network analysis between phage-infected bacteria reveals that hosts from multiple species, ecosystems, and drug-resistance phenotypes share numerous phages. Lastly, we show that phages throughout this network can package foreign genetic material enclosing an antibiotic resistance marker at various frequencies. Our findings indicate a weak host specialism of the tested phages, and therefore their potential to promote horizontal gene transfer in this environment.

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-27037-6

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DOI: 10.1038/s41467-021-27037-6

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