A somatic proteoglycan controls Notch-directed germ cell fate

Sandeep Gopal (), Aqilah Amran, Andre Elton, Leelee Ng and Roger Pocock ()
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Sandeep Gopal: Monash University
Aqilah Amran: Monash University
Andre Elton: Monash University
Leelee Ng: Monash University
Roger Pocock: Monash University

Nature Communications, 2021, vol. 12, issue 1, 1-13

Abstract: Abstract Communication between the soma and germline optimizes germ cell fate programs. Notch receptors are key determinants of germ cell fate but how somatic signals direct Notch-dependent germ cell behavior is undefined. Here we demonstrate that SDN-1 (syndecan-1), a somatic transmembrane proteoglycan, controls expression of the GLP-1 (germline proliferation-1) Notch receptor in the Caenorhabditis elegans germline. We find that SDN-1 control of a somatic TRP calcium channel governs calcium-dependent binding of an AP-2 transcription factor (APTF-2) to the glp-1 promoter. Hence, SDN-1 signaling promotes GLP-1 expression and mitotic germ cell fate. Together, these data reveal SDN-1 as a putative communication nexus between the germline and its somatic environment to control germ cell fate decisions.

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-27039-4

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DOI: 10.1038/s41467-021-27039-4

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