Multifactorial seroprofiling dissects the contribution of pre-existing human coronaviruses responses to SARS-CoV-2 immunity

Irene A. Abela, Chloé Pasin, Magdalena Schwarzmüller, Selina Epp, Michèle E. Sickmann, Merle M. Schanz, Peter Rusert, Jacqueline Weber, Stefan Schmutz, Annette Audigé, Liridona Maliqi, Annika Hunziker, Maria C. Hesselman, Cyrille R. Niklaus, Jochen Gottschalk, Eméry Schindler, Alexander Wepf, Urs Karrer, Aline Wolfensberger, Silvana K. Rampini, Patrick M. Meyer Sauteur, Christoph Berger, Michael Huber, Jürg Böni, Dominique L. Braun, Maddalena Marconato, Markus G. Manz, Beat M. Frey, Huldrych F. Günthard (), Roger D. Kouyos () and Alexandra Trkola ()
Additional contact information
Irene A. Abela: University of Zurich
Chloé Pasin: University of Zurich
Magdalena Schwarzmüller: University of Zurich
Selina Epp: University of Zurich
Michèle E. Sickmann: University of Zurich
Merle M. Schanz: University of Zurich
Peter Rusert: University of Zurich
Jacqueline Weber: University of Zurich
Stefan Schmutz: University of Zurich
Annette Audigé: University of Zurich
Liridona Maliqi: University of Zurich
Annika Hunziker: University of Zurich
Maria C. Hesselman: University of Zurich
Cyrille R. Niklaus: University of Zurich
Jochen Gottschalk: Blood Transfusion Service Zurich
Eméry Schindler: Blood Transfusion Service Zurich
Alexander Wepf: Cantonal Hospital Winterthur
Urs Karrer: Cantonal Hospital Winterthur
Aline Wolfensberger: University Hospital Zurich
Silvana K. Rampini: University Hospital Zurich
Patrick M. Meyer Sauteur: University Children’s Hospital Zurich
Christoph Berger: University Children’s Hospital Zurich
Michael Huber: University of Zurich
Jürg Böni: University of Zurich
Dominique L. Braun: University of Zurich
Maddalena Marconato: University Hospital and University of Zurich
Markus G. Manz: University Hospital and University of Zurich
Beat M. Frey: Blood Transfusion Service Zurich
Huldrych F. Günthard: University of Zurich
Roger D. Kouyos: University of Zurich
Alexandra Trkola: University of Zurich

Nature Communications, 2021, vol. 12, issue 1, 1-18

Abstract: Abstract Determination of SARS-CoV-2 antibody responses in the context of pre-existing immunity to circulating human coronavirus (HCoV) is critical for understanding protective immunity. Here we perform a multifactorial analysis of SARS-CoV-2 and HCoV antibody responses in pre-pandemic (N = 825) and SARS-CoV-2-infected donors (N = 389) using a custom-designed multiplex ABCORA assay. ABCORA seroprofiling, when combined with computational modeling, enables accurate definition of SARS-CoV-2 seroconversion and prediction of neutralization activity, and reveals intriguing interrelations with HCoV immunity. Specifically, higher HCoV antibody levels in SARS-CoV-2-negative donors suggest that pre-existing HCoV immunity may provide protection against SARS-CoV-2 acquisition. In those infected, higher HCoV activity is associated with elevated SARS-CoV-2 responses, indicating cross-stimulation. Most importantly, HCoV immunity may impact disease severity, as patients with high HCoV reactivity are less likely to require hospitalization. Collectively, our results suggest that HCoV immunity may promote rapid development of SARS-CoV-2-specific immunity, thereby underscoring the importance of exploring cross-protective responses for comprehensive coronavirus prevention.

Date: 2021
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DOI: 10.1038/s41467-021-27040-x

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