Electrochemical C–N bond activation for deaminative reductive coupling of Katritzky salts

Yeqing Liu, Xiangzhang Tao, Yu Mao, Xin Yuan, Jiangkai Qiu, Linyu Kong, Shengyang Ni (), Kai Guo (), Yi Wang () and Yi Pan
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Yeqing Liu: Nanjing University
Xiangzhang Tao: Nanjing University
Yu Mao: Nanjing University
Xin Yuan: Nanjing Tech University
Jiangkai Qiu: Nanjing Tech University
Linyu Kong: Nanjing University
Shengyang Ni: Nanjing University
Kai Guo: Nanjing Tech University
Yi Wang: Nanjing University
Yi Pan: Nanjing University

Nature Communications, 2021, vol. 12, issue 1, 1-7

Abstract: Abstract Electrosynthesis has received great attention among researchers in both academia and industry as an ideal technique to promote single electron reduction without the use of expensive catalysts. In this work, we report the electrochemical reduction of Katritzky salts to alkyl radicals by sacrificing the easily accessible metal anode. This catalyst and electrolyte free platform has broad applicability to single electron transfer chemistry, including fluoroalkenylation, alkynylation and thiolation. The deaminative functionalization is facilitated by the rapid molecular diffusion across microfluidic channels, demonstrating the practicality that outpaces the conventional electrochemistry setups.

Date: 2021
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DOI: 10.1038/s41467-021-27060-7

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