Listeria monocytogenes faecal carriage is common and depends on the gut microbiota

Lukas Hafner, Maxime Pichon, Christophe Burucoa, Sophie H. A. Nusser, Alexandra Moura, Marc Garcia-Garcera and Marc Lecuit ()
Additional contact information
Lukas Hafner: Institut Pasteur, Université de Paris, Inserm U1117, Biology of Infection Unit
Maxime Pichon: University Hospital of Poitiers, Infectious Agents Department, Bacteriology and Infection Control Laboratory
Christophe Burucoa: University Hospital of Poitiers, Infectious Agents Department, Bacteriology and Infection Control Laboratory
Sophie H. A. Nusser: Institut Pasteur, Université de Paris, Inserm U1117, Biology of Infection Unit
Alexandra Moura: Institut Pasteur, Université de Paris, Inserm U1117, Biology of Infection Unit
Marc Garcia-Garcera: University of Lausanne, Department of Fundamental Microbiology
Marc Lecuit: Institut Pasteur, Université de Paris, Inserm U1117, Biology of Infection Unit

Nature Communications, 2021, vol. 12, issue 1, 1-13

Abstract: Abstract Listeria genus comprises two pathogenic species, L. monocytogenes (Lm) and L. ivanovii, and non-pathogenic species. All can thrive as saprophytes, whereas only pathogenic species cause systemic infections. Identifying Listeria species’ respective biotopes is critical to understand the ecological contribution of Listeria virulence. In order to investigate the prevalence and abundance of Listeria species in various sources, we retrieved and analyzed 16S rRNA datasets from MG-RAST metagenomic database. 26% of datasets contain Listeria sensu stricto sequences, and Lm is the most prevalent species, most abundant in soil and host-associated environments, including 5% of human stools. Lm is also detected in 10% of human stool samples from an independent cohort of 900 healthy asymptomatic donors. A specific microbiota signature is associated with Lm faecal carriage, both in humans and experimentally inoculated mice, in which it precedes Lm faecal carriage. These results indicate that Lm faecal carriage is common and depends on the gut microbiota, and suggest that Lm faecal carriage is a crucial yet overlooked consequence of its virulence.

Date: 2021
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-021-27069-y Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-27069-y

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-021-27069-y

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().