Molecular and phenotypic profiling of colorectal cancer patients in West Africa reveals biological insights

Alatise, Olusegun Isaac; Knapp, Gregory C.; Sharma, Avinash; Chatila, Walid K.; Arowolo, Olukayode A.; Olasehinde, Olalekan; Famurewa, Olusola C.; Omisore, Adeleye D.; Komolafe, Akinwumi O.; Olaofe, Olaejinrinde O.; Katung, Aba I.; Ibikunle, David E.; Egberongbe, Adedeji A.; Olatoke, Samuel A.; Agodirin, Sulaiman O.; Adesiyun, Olusola A.; Adeyeye, Ademola; Kolawole, Oladapo A.; Olakanmi, Akinwumi O.; Arora, Kanika; Constable, Jeremy; Shah, Ronak; Basunia, Azfar; Sylvester, Brooke; Wu, Chao; Weiser, Martin R.; Seier, Ken; Gonen, Mithat; Stadler, Zsofia K.; Kemel, Yelena; Vakiani, Efsevia; Berger, Michael F.; Chan, Timothy A.; Solit, David B.; Shia, Jinru; Sanchez-Vega, Francisco; Schultz, Nikolaus; Brennan, Murray; Smith, J. Joshua; Kingham, T. Peter

Molecular and phenotypic profiling of colorectal cancer patients in West Africa reveals biological insights

Olusegun Isaac Alatise, Gregory C. Knapp, Avinash Sharma, Walid K. Chatila, Olukayode A. Arowolo, Olalekan Olasehinde, Olusola C. Famurewa, Adeleye D. Omisore, Akinwumi O. Komolafe, Olaejinrinde O. Olaofe, Aba I. Katung, David E. Ibikunle, Adedeji A. Egberongbe, Samuel A. Olatoke, Sulaiman O. Agodirin, Olusola A. Adesiyun, Ademola Adeyeye, Oladapo A. Kolawole, Akinwumi O. Olakanmi, Kanika Arora, Jeremy Constable, Ronak Shah, Azfar Basunia, Brooke Sylvester, Chao Wu, Martin R. Weiser, Ken Seier, Mithat Gonen, Zsofia K. Stadler, Yelena Kemel, Efsevia Vakiani, Michael F. Berger, Timothy A. Chan, David B. Solit, Jinru Shia, Francisco Sanchez-Vega, Nikolaus Schultz, Murray Brennan, J. Joshua Smith and T. Peter Kingham ()
Additional contact information
Olusegun Isaac Alatise: Obafemi Awolowo University
Gregory C. Knapp: Memorial Sloan Kettering Cancer Center
Avinash Sharma: Memorial Sloan Kettering Cancer Center
Walid K. Chatila: Memorial Sloan Kettering Cancer Center
Olukayode A. Arowolo: Obafemi Awolowo University
Olalekan Olasehinde: Obafemi Awolowo University
Olusola C. Famurewa: Obafemi Awolowo University
Adeleye D. Omisore: Obafemi Awolowo University
Akinwumi O. Komolafe: Obafemi Awolowo University
Olaejinrinde O. Olaofe: Obafemi Awolowo University
Aba I. Katung: Federal Medical Centre
David E. Ibikunle: Federal Medical Centre
Adedeji A. Egberongbe: Federal Medical Centre
Samuel A. Olatoke: University of Ilorin Teaching Hospital
Sulaiman O. Agodirin: University of Ilorin Teaching Hospital
Olusola A. Adesiyun: University of Ilorin Teaching Hospital
Ademola Adeyeye: University of Ilorin Teaching Hospital
Oladapo A. Kolawole: Ladoke Akintola University of Technology
Akinwumi O. Olakanmi: University of Medical Sciences
Kanika Arora: Memorial Sloan Kettering Cancer Center
Jeremy Constable: Memorial Sloan Kettering Cancer Center
Ronak Shah: Memorial Sloan Kettering Cancer Center
Azfar Basunia: Memorial Sloan Kettering Cancer Center
Brooke Sylvester: Memorial Sloan Kettering Cancer Center
Chao Wu: Memorial Sloan Kettering Cancer Center
Martin R. Weiser: Memorial Sloan Kettering Cancer Center
Ken Seier: Memorial Sloan Kettering Cancer Center
Mithat Gonen: Memorial Sloan Kettering Cancer Center
Zsofia K. Stadler: Memorial Sloan Kettering Cancer Center
Yelena Kemel: Memorial Sloan Kettering Cancer Center
Efsevia Vakiani: Memorial Sloan Kettering Cancer Center
Michael F. Berger: Memorial Sloan Kettering Cancer Center
Timothy A. Chan: Memorial Sloan Kettering Cancer Center
David B. Solit: Memorial Sloan Kettering Cancer Center
Jinru Shia: Memorial Sloan Kettering Cancer Center
Francisco Sanchez-Vega: Memorial Sloan Kettering Cancer Center
Nikolaus Schultz: Memorial Sloan Kettering Cancer Center
Murray Brennan: Memorial Sloan Kettering Cancer Center
J. Joshua Smith: Memorial Sloan Kettering Cancer Center
T. Peter Kingham: Memorial Sloan Kettering Cancer Center

Nature Communications, 2021, vol. 12, issue 1, 1-8

Abstract: Abstract Understanding the molecular and phenotypic profile of colorectal cancer (CRC) in West Africa is vital to addressing the regions rising burden of disease. Tissue from unselected Nigerian patients was analyzed with a multigene, next-generation sequencing assay. The rate of microsatellite instability is significantly higher among Nigerian CRC patients (28.1%) than patients from The Cancer Genome Atlas (TCGA, 14.2%) and Memorial Sloan Kettering Cancer Center (MSKCC, 8.5%, P

Date: 2021
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DOI: 10.1038/s41467-021-27106-w

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