Dysbiosis of human gut microbiome in young-onset colorectal cancer

Yongzhi Yang, Lutao Du, Debing Shi, Cheng Kong, Jianqiang Liu, Guang Liu, Xinxiang Li and Yanlei Ma ()
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Yongzhi Yang: Fudan University Shanghai Cancer Center
Lutao Du: The Second Hospital of Shandong University
Debing Shi: Fudan University Shanghai Cancer Center
Cheng Kong: Shanghai Tenth People’s Hospital Affiliated to Tongji University
Jianqiang Liu: Fudan University Shanghai Cancer Center
Guang Liu: Quantum Hi-Tech Microecological Medical (Guangdong) Co.,Ltd.
Xinxiang Li: Fudan University Shanghai Cancer Center
Yanlei Ma: Fudan University Shanghai Cancer Center

Nature Communications, 2021, vol. 12, issue 1, 1-13

Abstract: Abstract The incidence of sporadic young-onset colorectal cancer (yCRC) is increasing. A significant knowledge gap exists in the gut microbiota and its diagnostic value for yCRC patients. Through 16S rRNA gene sequencing, 728 samples are collected to identify microbial markers, and an independent cohort of 310 samples is used to validate the results. Furthermore, species-level and functional analysis are performed by metagenome sequencing using 200 samples. Gut microbial diversity is increased in yCRC. Flavonifractor plautii is an important bacterial species in yCRC, while genus Streptococcus contains the key phylotype in the old-onset colorectal cancer. Functional analysis reveals that yCRC has unique characteristics of bacterial metabolism characterized by the dominance of DNA binding and RNA-dependent DNA biosynthetic process. The random forest classifier model achieves a powerful classification potential. This study highlights the potential of the gut microbiota biomarkers as a promising non-invasive tool for the accurate detection and distinction of individuals with yCRC.

Date: 2021
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DOI: 10.1038/s41467-021-27112-y

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