Functional convalescent plasma antibodies and pre-infusion titers shape the early severe COVID-19 immune response

Jonathan D. Herman, Chuangqi Wang, Carolin Loos, Hyunah Yoon, Johanna Rivera, M. Eugenia Dieterle, Denise Haslwanter, Rohit K. Jangra, Robert H. Bortz, Katharine J. Bar, Boris Julg, Kartik Chandran, Douglas Lauffenburger (), Liise-anne Pirofski () and Galit Alter ()
Additional contact information
Jonathan D. Herman: Ragon Institute of MGH, MIT, and Harvard
Chuangqi Wang: Massachusetts Institute of Technology
Carolin Loos: Ragon Institute of MGH, MIT, and Harvard
Hyunah Yoon: Albert Einstein College of Medicine and Montefiore Medical Center
Johanna Rivera: Albert Einstein College of Medicine and Montefiore Medical Center
M. Eugenia Dieterle: Albert Einstein College of Medicine
Denise Haslwanter: Albert Einstein College of Medicine
Rohit K. Jangra: Louisiana State University Health Science Center-Shreveport
Robert H. Bortz: Albert Einstein College of Medicine
Katharine J. Bar: University of Pennsylvania
Boris Julg: Ragon Institute of MGH, MIT, and Harvard
Kartik Chandran: Albert Einstein College of Medicine
Douglas Lauffenburger: Massachusetts Institute of Technology
Liise-anne Pirofski: Albert Einstein College of Medicine and Montefiore Medical Center
Galit Alter: Ragon Institute of MGH, MIT, and Harvard

Nature Communications, 2021, vol. 12, issue 1, 1-11

Abstract: Abstract Transfer of convalescent plasma (CP) had been proposed early during the SARS-CoV-2 pandemic as an accessible therapy, yet trial results worldwide have been mixed, potentially due to the heterogeneous nature of CP. Here we perform deep profiling of SARS-CoV-2-specific antibody titer, Fc-receptor binding, and Fc-mediated functional assays in CP units, as well as in plasma from hospitalized COVID-19 patients before and after CP administration. The profiling results show that, although all recipients exhibit expanded SARS-CoV-2-specific humoral immune responses, CP units contain more functional antibodies than recipient plasma. Meanwhile, CP functional profiles influence the evolution of recipient humoral immunity in conjuncture with the recipient’s pre-existing SARS-CoV2-specific antibody titers: CP-derived SARS-CoV-2 nucleocapsid-specific antibody functions are associated with muted humoral immune evolution in patients with high titer anti-spike IgG. Our data thus provide insights into the unexpected impact of CP-derived functional anti-spike and anti-nucleocapsid antibodies on the evolution of SARS-CoV-2-specific response following severe infection.

Date: 2021
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/s41467-021-27201-y Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-27201-y

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-021-27201-y

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().