Atlas of RNA editing events affecting protein expression in aged and Alzheimer’s disease human brain tissue

Yiyi Ma, Eric B. Dammer, Daniel Felsky, Duc M. Duong, Hans-Ulrich Klein, Charles C. White, Maotian Zhou, Benjamin A. Logsdon, Cristin McCabe, Jishu Xu, Minghui Wang, Thomas S. Wingo, James J. Lah, Bin Zhang, Julie Schneider, Mariet Allen, Xue Wang, Nilüfer Ertekin-Taner, Nicholas T. Seyfried, Allan I. Levey, David A. Bennett and Philip L. De Jager ()
Additional contact information
Yiyi Ma: Columbia University Medical Center
Eric B. Dammer: Emory University School of Medicine
Daniel Felsky: Centre for Addiction and Mental Health
Duc M. Duong: Emory University School of Medicine
Hans-Ulrich Klein: Columbia University Medical Center
Charles C. White: Broad Institute
Maotian Zhou: Emory University School of Medicine
Benjamin A. Logsdon: Sage Bionetworks
Cristin McCabe: Broad Institute
Jishu Xu: Rush University Medical Center
Minghui Wang: Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place
Thomas S. Wingo: Emory University School of Medicine
James J. Lah: Emory University School of Medicine
Bin Zhang: Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place
Julie Schneider: Rush University Medical Center
Mariet Allen: Mayo Clinic Florida, Department of Neuroscience
Xue Wang: Mayo Clinic Florida, Department of Health Sciences Research
Nilüfer Ertekin-Taner: Mayo Clinic Florida, Department of Neuroscience
Nicholas T. Seyfried: Emory University School of Medicine
Allan I. Levey: Emory University School of Medicine
David A. Bennett: Rush University Medical Center
Philip L. De Jager: Columbia University Medical Center

Nature Communications, 2021, vol. 12, issue 1, 1-16

Abstract: Abstract RNA editing is a feature of RNA maturation resulting in the formation of transcripts whose sequence differs from the genome template. Brain RNA editing may be altered in Alzheimer’s disease (AD). Here, we analyzed data from 1,865 brain samples covering 9 brain regions from 1,074 unrelated subjects on a transcriptome-wide scale to identify inter-regional differences in RNA editing. We expand the list of known brain editing events by identifying 58,761 previously unreported events. We note that only a small proportion of these editing events are found at the protein level in our proteome-wide validation effort. We also identified the occurrence of editing events associated with AD dementia, neuropathological measures and longitudinal cognitive decline in: SYT11, MCUR1, SOD2, ORAI2, HSDL2, PFKP, and GPRC5B. Thus, we present an extended reference set of brain RNA editing events, identify a subset that are found to be expressed at the protein level, and extend the narrative of transcriptomic perturbation in AD to RNA editing.

Date: 2021
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/s41467-021-27204-9 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-27204-9

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-021-27204-9

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().