Self-activating anti-infection implant

Jieni Fu, Weidong Zhu, Xiangmei Liu (), Chunyong Liang (), Yufeng Zheng, Zhaoyang Li, Yanqin Liang, Dong Zheng, Shengli Zhu, Zhenduo Cui and Shuilin Wu ()
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Jieni Fu: Tianjin University
Weidong Zhu: Hebei University of Technology
Xiangmei Liu: Hebei University of Technology
Chunyong Liang: Hebei University of Technology
Yufeng Zheng: Peking University
Zhaoyang Li: Tianjin University
Yanqin Liang: Tianjin University
Dong Zheng: Huazhong University of Science and Technology
Shengli Zhu: Tianjin University
Zhenduo Cui: Tianjin University
Shuilin Wu: Tianjin University

Nature Communications, 2021, vol. 12, issue 1, 1-13

Abstract: Abstract Clinically, it is difficult to endow implants with excellent osteogenic ability and antibacterial activity simultaneously. Herein, the self-activating implants modified with hydroxyapatite (HA)/MoS2 coating are designed to prevent Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) infections and accelerate bone regeneration simultaneously. The electron transfer between bacteria and HA/MoS2 is triggered when bacteria contacted with the material. RNA sequencing data reveals that the expression level of anaerobic respiration–related genes is up-regulated and the expression level of aerobic respiration–related genes is down-regulated when bacteria adhere to the implants. HA/MoS2 presents a highly effective antibacterial efficacy against both S. aureus and E. coli because of bacterial respiration–activated metabolic pathway changes. Meanwhile, this coating promotes the osteoblastic differentiation of mesenchymal stem cells by altering the potentials of cell membrane and mitochondrial membrane. The proposed strategy exhibits great potential to endow implants with self-activating anti-infection performance and osteogenic ability simultaneously.

Date: 2021
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DOI: 10.1038/s41467-021-27217-4

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