The telomere length landscape of prostate cancer

Julie Livingstone, Yu-Jia Shiah, Takafumi N. Yamaguchi, Lawrence E. Heisler, Vincent Huang, Robert Lesurf, Tsumugi Gebo, Benjamin Carlin, Stefan Eng, Erik Drysdale, Jeffrey Green, Theodorus Kwast, Robert G. Bristow, Michael Fraser and Paul C. Boutros ()
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Julie Livingstone: University of California
Yu-Jia Shiah: Ontario Institute for Cancer Research
Takafumi N. Yamaguchi: University of California
Lawrence E. Heisler: Ontario Institute for Cancer Research
Vincent Huang: Ontario Institute for Cancer Research
Robert Lesurf: Ontario Institute for Cancer Research
Tsumugi Gebo: University of California
Benjamin Carlin: University of California
Stefan Eng: University of California
Erik Drysdale: Ontario Institute for Cancer Research
Jeffrey Green: Ontario Institute for Cancer Research
Theodorus Kwast: University Health Network
Robert G. Bristow: University Health Network
Michael Fraser: University Health Network
Paul C. Boutros: University of California

Nature Communications, 2021, vol. 12, issue 1, 1-13

Abstract: Abstract Replicative immortality is a hallmark of cancer, and can be achieved through telomere lengthening and maintenance. Although the role of telomere length in cancer has been well studied, its association to genomic features is less well known. Here, we report the telomere lengths of 392 localized prostate cancer tumours and characterize their relationship to genomic, transcriptomic and proteomic features. Shorter tumour telomere lengths are associated with elevated genomic instability, including single-nucleotide variants, indels and structural variants. Genes involved in cell proliferation and signaling are correlated with tumour telomere length at all levels of the central dogma. Telomere length is also associated with multiple clinical features of a tumour. Longer telomere lengths in non-tumour samples are associated with a lower rate of biochemical relapse. In summary, we describe the multi-level integration of telomere length, genomics, transcriptomics and proteomics in localized prostate cancer.

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-27223-6

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DOI: 10.1038/s41467-021-27223-6

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