Meta-analyses identify DNA methylation associated with kidney function and damage

Pascal Schlosser (), Adrienne Tin, Pamela R. Matias-Garcia, Chris H. L. Thio, Roby Joehanes, Hongbo Liu, Antoine Weihs, Zhi Yu, Anselm Hoppmann, Franziska Grundner-Culemann, Josine L. Min, Adebowale A. Adeyemo, Charles Agyemang, Johan Ärnlöv, Nasir A. Aziz, Andrea Baccarelli, Murielle Bochud, Hermann Brenner, Monique M. B. Breteler, Cristian Carmeli, Layal Chaker, John C. Chambers, Shelley A. Cole, Josef Coresh, Tanguy Corre, Adolfo Correa, Simon R. Cox, Niek Klein, Graciela E. Delgado, Arce Domingo-Relloso, Kai-Uwe Eckardt, Arif B. Ekici, Karlhans Endlich, Kathryn L. Evans, James S. Floyd, Myriam Fornage, Lude Franke, Eliza Fraszczyk, Xu Gao, Xīn Gào, Mohsen Ghanbari, Sahar Ghasemi, Christian Gieger, Philip Greenland, Megan L. Grove, Sarah E. Harris, Gibran Hemani, Peter Henneman, Christian Herder, Steve Horvath, Lifang Hou, Mikko A. Hurme, Shih-Jen Hwang, Marjo-Riitta Jarvelin, Sharon L. R. Kardia, Silva Kasela, Marcus E. Kleber, Wolfgang Koenig, Jaspal S. Kooner, Holly Kramer, Florian Kronenberg, Brigitte Kühnel, Terho Lehtimäki, Lars Lind, Dan Liu, Yongmei Liu, Donald M. Lloyd-Jones, Kurt Lohman, Stefan Lorkowski, Ake T. Lu, Riccardo E. Marioni, Winfried März, Daniel L. McCartney, Karlijn A. C. Meeks, Lili Milani, Pashupati P. Mishra, Matthias Nauck, Ana Navas-Acien, Christoph Nowak, Annette Peters, Holger Prokisch, Bruce M. Psaty, Olli T. Raitakari, Scott M. Ratliff, Alex P. Reiner, Sylvia E. Rosas, Ben Schöttker, Joel Schwartz, Sanaz Sedaghat, Jennifer A. Smith, Nona Sotoodehnia, Hannah R. Stocker, Silvia Stringhini, Johan Sundström, Brenton R. Swenson, Maria Tellez-Plaza, Joyce B. J. Meurs, Jana V. Vliet-Ostaptchouk, Andrea Venema, Niek Verweij, Rosie M. Walker, Matthias Wielscher, Juliane Winkelmann, Bruce H. R. Wolffenbuttel, Wei Zhao, Yinan Zheng, Marie Loh, Harold Snieder, Daniel Levy, Melanie Waldenberger, Katalin Susztak, Anna Köttgen and Alexander Teumer ()
Additional contact information
Pascal Schlosser: Faculty of Medicine and Medical Center - University of Freiburg
Adrienne Tin: Johns Hopkins Bloomberg School of Public Health
Pamela R. Matias-Garcia: German Research Center for Environmental Health
Chris H. L. Thio: University of Groningen, University Medical Center Groningen
Roby Joehanes: Framingham Heart Study
Hongbo Liu: University of Pennsylvania Perelman School of Medicine
Antoine Weihs: University Medicine Greifswald
Zhi Yu: Broad Institute
Anselm Hoppmann: Faculty of Medicine and Medical Center - University of Freiburg
Franziska Grundner-Culemann: Faculty of Medicine and Medical Center - University of Freiburg
Josine L. Min: University of Bristol
Adebowale A. Adeyemo: National Institutes of Health
Charles Agyemang: University of Amsterdam
Johan Ärnlöv: Karolinska Institutet
Nasir A. Aziz: German Centre for Neurodegenerative Diseases (DZNE)
Andrea Baccarelli: Columbia University
Murielle Bochud: University of Lausanne
Hermann Brenner: Division of Clinical Epidemiology and Aging Research
Monique M. B. Breteler: German Centre for Neurodegenerative Diseases (DZNE)
Cristian Carmeli: University of Lausanne
Layal Chaker: Erasmus University Medical Center
John C. Chambers: Nanyang Technological University
Shelley A. Cole: Texas Biomedical Research Institute
Josef Coresh: Johns Hopkins Bloomberg School of Public Health
Tanguy Corre: University of Lausanne
Adolfo Correa: University of Mississippi Medical Center
Simon R. Cox: The University of Edinburgh
Niek Klein: University Medical Center Groningen, University of Groningen
Graciela E. Delgado: Heidelberg University
Arce Domingo-Relloso: Carlos III Health Institute
Kai-Uwe Eckardt: University of Erlangen-Nürnberg
Arif B. Ekici: Friedrich-Alexander-UniversitätErlangen-Nürnberg
Karlhans Endlich: University Medicine Greifswald
Kathryn L. Evans: University of Edinburgh
James S. Floyd: University of Washington
Myriam Fornage: McGovern Medical School
Lude Franke: University Medical Center Groningen, University of Groningen
Eliza Fraszczyk: University of Groningen, University Medical Center Groningen
Xu Gao: Columbia University
Xīn Gào: Division of Clinical Epidemiology and Aging Research
Mohsen Ghanbari: Erasmus University Medical Center
Sahar Ghasemi: University Medicine Greifswald
Christian Gieger: German Research Center for Environmental Health
Philip Greenland: Northwestern University Feinberg School of Medicine
Megan L. Grove: The University of Texas Health Science Center at Houston
Sarah E. Harris: The University of Edinburgh
Gibran Hemani: University of Bristol
Peter Henneman: Amsterdam University Medical Centres, University of Amsterdam
Christian Herder: Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf
Steve Horvath: University of California Los Angeles
Lifang Hou: Northwestern University Feinberg School of Medicine
Mikko A. Hurme: Tampere University
Shih-Jen Hwang: Framingham Heart Study
Marjo-Riitta Jarvelin: Imperial College London
Sharon L. R. Kardia: University of Michigan
Silva Kasela: University of Tartu
Marcus E. Kleber: Heidelberg University
Wolfgang Koenig: Technische Universität München
Jaspal S. Kooner: London North West Healthcare NHS Trust
Holly Kramer: Loyola University Chicago
Florian Kronenberg: Medical University of Innsbruck
Brigitte Kühnel: German Research Center for Environmental Health
Terho Lehtimäki: Tampere University
Lars Lind: Uppsala University
Dan Liu: German Centre for Neurodegenerative Diseases (DZNE)
Yongmei Liu: Duke University School of Medicine
Donald M. Lloyd-Jones: Northwestern University Feinberg School of Medicine
Kurt Lohman: Duke University School of Medicine
Stefan Lorkowski: Friedrich Schiller University Jena
Ake T. Lu: University of California Los Angeles
Riccardo E. Marioni: University of Edinburgh
Winfried März: Heidelberg University
Daniel L. McCartney: University of Edinburgh
Karlijn A. C. Meeks: National Institutes of Health
Lili Milani: University of Tartu
Pashupati P. Mishra: Tampere University
Matthias Nauck: Partner Site Greifswald
Ana Navas-Acien: Columbia University Mailman School of Public Health
Christoph Nowak: Karolinska Institutet
Annette Peters: German Research Center for Environmental Health
Holger Prokisch: Technische Universität München
Bruce M. Psaty: University of Washington
Olli T. Raitakari: University of Turku
Scott M. Ratliff: University of Michigan
Alex P. Reiner: University of Washington
Sylvia E. Rosas: Joslin Diabetes Center
Ben Schöttker: Division of Clinical Epidemiology and Aging Research
Joel Schwartz: Harvard T.H. Chan School of Public Health
Sanaz Sedaghat: University of Minnesota
Jennifer A. Smith: University of Michigan
Nona Sotoodehnia: University of Washington
Hannah R. Stocker: Division of Clinical Epidemiology and Aging Research
Silvia Stringhini: University of Lausanne
Johan Sundström: Uppsala University
Brenton R. Swenson: University of Washington
Maria Tellez-Plaza: Carlos III Health Institute
Joyce B. J. Meurs: Erasmus Medical Center
Jana V. Vliet-Ostaptchouk: University of Groningen, University Medical Center Groningen
Andrea Venema: Amsterdam University Medical Centres, University of Amsterdam
Niek Verweij: University Medical Center Groningen, University of Groningen
Rosie M. Walker: University of Edinburgh
Matthias Wielscher: Imperial College London
Juliane Winkelmann: Technische Universität München
Bruce H. R. Wolffenbuttel: University of Groningen, University Medical Center Groningen
Wei Zhao: University of Michigan
Yinan Zheng: Northwestern University Feinberg School of Medicine
Marie Loh: Nanyang Technological University
Harold Snieder: University of Groningen, University Medical Center Groningen
Daniel Levy: Framingham Heart Study
Melanie Waldenberger: German Research Center for Environmental Health
Katalin Susztak: University of Pennsylvania Perelman School of Medicine
Anna Köttgen: Faculty of Medicine and Medical Center - University of Freiburg
Alexander Teumer: Partner Site Greifswald

Nature Communications, 2021, vol. 12, issue 1, 1-16

Abstract: Abstract Chronic kidney disease is a major public health burden. Elevated urinary albumin-to-creatinine ratio is a measure of kidney damage, and used to diagnose and stage chronic kidney disease. To extend the knowledge on regulatory mechanisms related to kidney function and disease, we conducted a blood-based epigenome-wide association study for estimated glomerular filtration rate (n = 33,605) and urinary albumin-to-creatinine ratio (n = 15,068) and detected 69 and seven CpG sites where DNA methylation was associated with the respective trait. The majority of these findings showed directionally consistent associations with the respective clinical outcomes chronic kidney disease and moderately increased albuminuria. Associations of DNA methylation with kidney function, such as CpGs at JAZF1, PELI1 and CHD2 were validated in kidney tissue. Methylation at PHRF1, LDB2, CSRNP1 and IRF5 indicated causal effects on kidney function. Enrichment analyses revealed pathways related to hemostasis and blood cell migration for estimated glomerular filtration rate, and immune cell activation and response for urinary albumin-to-creatinineratio-associated CpGs.

Date: 2021
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (4)

Downloads: (external link)
https://www.nature.com/articles/s41467-021-27234-3 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-27234-3

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-021-27234-3

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().