Dietary essential amino acids restore liver metabolism in ovariectomized mice via hepatic estrogen receptor α

Sara Della Torre (), Valeria Benedusi, Giovanna Pepe, Clara Meda, Nicoletta Rizzi, Nina Henriette Uhlenhaut and Adriana Maggi ()
Additional contact information
Sara Della Torre: University of Milan
Valeria Benedusi: University of Milan
Giovanna Pepe: University of Milan
Clara Meda: University of Milan
Nicoletta Rizzi: University of Milan
Nina Henriette Uhlenhaut: Institute for Diabetes and Cancer (IDC), Helmholz Zentrum Munich, Helmholtz Diabetes Center (HMGU)
Adriana Maggi: University of Milan

Nature Communications, 2021, vol. 12, issue 1, 1-13

Abstract: Abstract In female mammals, the cessation of ovarian functions is associated with significant metabolic alterations, weight gain, and increased susceptibility to a number of pathologies associated with ageing. The molecular mechanisms triggering these systemic events are unknown because most tissues are responsive to lowered circulating sex steroids. As it has been demonstrated that isoform alpha of the estrogen receptor (ERα) may be activated by both estrogens and amino acids, we test the metabolic effects of a diet enriched in specific amino acids in ovariectomized (OVX) mice. This diet is able to block the OVX-induced weight gain and fat deposition in the liver. The use of liver-specific ERα KO mice demonstrates that the hepatic ERα, through the control of liver lipid metabolism, has a key role in the systemic response to OVX. The study suggests that the liver ERα might be a valuable target for dietary treatments for the post-menopause.

Date: 2021
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-021-27272-x Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-27272-x

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-021-27272-x

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().