Lipid droplet availability affects neural stem/progenitor cell metabolism and proliferation

Mergim Ramosaj, Sofia Madsen, Vanille Maillard, Valentina Scandella, Daniel Sudria-Lopez, Naoya Yuizumi, Ludovic Telley and Marlen Knobloch ()
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Mergim Ramosaj: University of Lausanne
Sofia Madsen: University of Lausanne
Vanille Maillard: University of Lausanne
Valentina Scandella: University of Lausanne
Daniel Sudria-Lopez: University of Lausanne
Naoya Yuizumi: The University of Tokyo
Ludovic Telley: University of Lausanne
Marlen Knobloch: University of Lausanne

Nature Communications, 2021, vol. 12, issue 1, 1-17

Abstract: Abstract Neural stem/progenitor cells (NSPCs) generate new neurons throughout adulthood. However, the underlying regulatory processes are still not fully understood. Lipid metabolism plays an important role in regulating NSPC activity: build-up of lipids is crucial for NSPC proliferation, whereas break-down of lipids has been shown to regulate NSPC quiescence. Despite their central role for cellular lipid metabolism, the role of lipid droplets (LDs), the lipid storing organelles, in NSPCs remains underexplored. Here we show that LDs are highly abundant in adult mouse NSPCs, and that LD accumulation is significantly altered upon fate changes such as quiescence and differentiation. NSPC proliferation is influenced by the number of LDs, inhibition of LD build-up, breakdown or usage, and the asymmetric inheritance of LDs during mitosis. Furthermore, high LD-containing NSPCs have increased metabolic activity and capacity, but do not suffer from increased oxidative damage. Together, these data indicate an instructive role for LDs in driving NSPC behaviour.

Date: 2021
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DOI: 10.1038/s41467-021-27365-7

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