A tough nitric oxide-eluting hydrogel coating suppresses neointimal hyperplasia on vascular stent

Yin Chen, Peng Gao, Lu Huang, Xing Tan, Ningling Zhou, Tong Yang, Hua Qiu, Xin Dai, Sean Michael, Qiufen Tu, Nan Huang, Zhihong Guo, Jianhua Zhou (), Zhilu Yang () and Hongkai Wu ()
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Yin Chen: Sun Yat-sen University
Peng Gao: Southwest Jiaotong University
Lu Huang: Sun Yat-sen University
Xing Tan: Southwest Jiaotong University
Ningling Zhou: Southwest Jiaotong University
Tong Yang: Southwest Jiaotong University
Hua Qiu: Southwest Jiaotong University
Xin Dai: The Hong Kong University of Science and Technology
Sean Michael: The Hong Kong University of Science and Technology
Qiufen Tu: Southwest Jiaotong University
Nan Huang: Southwest Jiaotong University
Zhihong Guo: The Hong Kong University of Science and Technology
Jianhua Zhou: Sun Yat-sen University
Zhilu Yang: Southwest Jiaotong University
Hongkai Wu: The Hong Kong University of Science and Technology

Nature Communications, 2021, vol. 12, issue 1, 1-16

Abstract: Abstract Vascular stent is viewed as one of the greatest advancements in interventional cardiology. However, current approved stents suffer from in-stent restenosis associated with neointimal hyperplasia or stent thrombosis. Herein, we develop a nitric oxide-eluting (NOE) hydrogel coating for vascular stents inspired by the biological functions of nitric oxide for cardiovascular system. Our NOE hydrogel is mechanically tough and could selectively facilitate the adhesion of endothelial cells. Besides, it is non-thrombotic and capable of inhibiting smooth muscle cells. Transcriptome analysis unravels the NOE hydrogel could modulate the inflammatory response and induce the relaxation of smooth muscle cells. In vivo study further demonstrates vascular stents coated with it promote rapid restoration of native endothelium, and persistently suppress inflammation and neointimal hyperplasia in both leporine and swine models. We expect such NOE hydrogel will open an avenue to the surface engineering of vascular implants for better clinical outcomes.

Date: 2021
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DOI: 10.1038/s41467-021-27368-4

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