Massive image-based single-cell profiling reveals high levels of circulating platelet aggregates in patients with COVID-19

Masako Nishikawa, Hiroshi Kanno, Yuqi Zhou, Ting-Hui Xiao (), Takuma Suzuki, Yuma Ibayashi, Jeffrey Harmon, Shigekazu Takizawa, Kotaro Hiramatsu, Nao Nitta, Risako Kameyama, Walker Peterson, Jun Takiguchi, Mohammad Shifat-E-Rabbi, Yan Zhuang, Xuwang Yin, Abu Hasnat Mohammad Rubaiyat, Yunjie Deng, Hongqian Zhang, Shigeki Miyata, Gustavo K. Rohde, Wataru Iwasaki, Yutaka Yatomi () and Keisuke Goda ()
Additional contact information
Masako Nishikawa: The University of Tokyo
Hiroshi Kanno: The University of Tokyo
Yuqi Zhou: The University of Tokyo
Ting-Hui Xiao: The University of Tokyo
Takuma Suzuki: The University of Tokyo
Yuma Ibayashi: The University of Tokyo
Jeffrey Harmon: The University of Tokyo
Shigekazu Takizawa: The University of Tokyo
Kotaro Hiramatsu: The University of Tokyo
Nao Nitta: CYBO, Inc
Risako Kameyama: The University of Tokyo
Walker Peterson: The University of Tokyo
Jun Takiguchi: The University of Tokyo
Mohammad Shifat-E-Rabbi: University of Virginia
Yan Zhuang: University of Virginia
Xuwang Yin: University of Virginia
Abu Hasnat Mohammad Rubaiyat: University of Virginia
Yunjie Deng: The University of Tokyo
Hongqian Zhang: The University of Tokyo
Shigeki Miyata: Japanese Red Cross Society
Gustavo K. Rohde: University of Virginia
Wataru Iwasaki: The University of Tokyo
Yutaka Yatomi: The University of Tokyo
Keisuke Goda: The University of Tokyo

Nature Communications, 2021, vol. 12, issue 1, 1-12

Abstract: Abstract A characteristic clinical feature of COVID-19 is the frequent incidence of microvascular thrombosis. In fact, COVID-19 autopsy reports have shown widespread thrombotic microangiopathy characterized by extensive diffuse microthrombi within peripheral capillaries and arterioles in lungs, hearts, and other organs, resulting in multiorgan failure. However, the underlying process of COVID-19-associated microvascular thrombosis remains elusive due to the lack of tools to statistically examine platelet aggregation (i.e., the initiation of microthrombus formation) in detail. Here we report the landscape of circulating platelet aggregates in COVID-19 obtained by massive single-cell image-based profiling and temporal monitoring of the blood of COVID-19 patients (n = 110). Surprisingly, our analysis of the big image data shows the anomalous presence of excessive platelet aggregates in nearly 90% of all COVID-19 patients. Furthermore, results indicate strong links between the concentration of platelet aggregates and the severity, mortality, respiratory condition, and vascular endothelial dysfunction level of COVID-19 patients.

Date: 2021
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DOI: 10.1038/s41467-021-27378-2

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