Free fatty-acid transport via CD36 drives β-oxidation-mediated hematopoietic stem cell response to infection

Jayna J. Mistry, Charlotte Hellmich, Jamie A. Moore, Aisha Jibril, Iain Macaulay, Mar Moreno-Gonzalez, Federica Palma, Naiara Beraza (), Kristian M. Bowles () and Stuart A. Rushworth ()
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Jayna J. Mistry: Norwich Medical School, University of East Anglia, Norwich Research Park
Charlotte Hellmich: Norwich Medical School, University of East Anglia, Norwich Research Park
Jamie A. Moore: Norwich Medical School, University of East Anglia, Norwich Research Park
Aisha Jibril: Norwich Medical School, University of East Anglia, Norwich Research Park
Iain Macaulay: Earlham Institute, Norwich Research Park
Mar Moreno-Gonzalez: Gut Microbes and Health Institute Strategic Programme, Quadram Institute
Federica Palma: Norwich Medical School, University of East Anglia, Norwich Research Park
Naiara Beraza: Gut Microbes and Health Institute Strategic Programme, Quadram Institute
Kristian M. Bowles: Norwich Medical School, University of East Anglia, Norwich Research Park
Stuart A. Rushworth: Norwich Medical School, University of East Anglia, Norwich Research Park

Nature Communications, 2021, vol. 12, issue 1, 1-13

Abstract: Abstract Acute infection is known to induce rapid expansion of hematopoietic stem cells (HSCs), but the mechanisms supporting this expansion remain incomplete. Using mouse models, we show that inducible CD36 is required for free fatty acid uptake by HSCs during acute infection, allowing the metabolic transition from glycolysis towards β-oxidation. Mechanistically, high CD36 levels promote FFA uptake, which enables CPT1A to transport fatty acyl chains from the cytosol into the mitochondria. Without CD36-mediated FFA uptake, the HSCs are unable to enter the cell cycle, subsequently enhancing mortality in response to bacterial infection. These findings enhance our understanding of HSC metabolism in the bone marrow microenvironment, which supports the expansion of HSCs during pathogenic challenge.

Date: 2021
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DOI: 10.1038/s41467-021-27460-9

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