Nanoparticle-assembled bioadhesive coacervate coating with prolonged gastrointestinal retention for inflammatory bowel disease therapy

Pengchao Zhao, Xianfeng Xia, Xiayi Xu, Kevin Kai Chung Leung, Aliza Rai, Yingrui Deng, Boguang Yang, Huasheng Lai, Xin Peng, Peng Shi, Honglu Zhang, Philip Wai Yan Chiu () and Liming Bian ()
Additional contact information
Pengchao Zhao: The Chinese University of Hong Kong
Xianfeng Xia: Sun Yat-sen University Cancer Center
Xiayi Xu: The Chinese University of Hong Kong
Kevin Kai Chung Leung: The Chinese University of Hong Kong
Aliza Rai: The Chinese University of Hong Kong
Yingrui Deng: The Chinese University of Hong Kong
Boguang Yang: The Chinese University of Hong Kong
Huasheng Lai: The Chinese University of Hong Kong
Xin Peng: The Chinese University of Hong Kong
Peng Shi: South China University of Technology
Honglu Zhang: South China University of Technology
Philip Wai Yan Chiu: The Chinese University of Hong Kong
Liming Bian: South China University of Technology

Nature Communications, 2021, vol. 12, issue 1, 1-13

Abstract: Abstract A key challenge for the effective treatment of gastrointestinal diseases including inflammatory bowel disease is to develop an orally administered drug delivery system capable of prolonged retention in the gastrointestinal tract. Herein we report a bioadhesive liquid coacervate based on hydrogen bonding-driven nanoparticle assembly. Free from electrostatic interactions, our fluid nanoparticle-assembled coacervate demonstrates significant pH- and salt-independent structural stability and forms a physically adhesive coating on a large surface area of intestinal tract with an extended residence time of more than 2 days to mediate the sustained release of preloaded water-soluble small molecule drugs in vivo. The orally administered drug-laden nanoparticle-assembled coacervate significantly mitigates the symptoms of inflammatory bowel disease, restores the diversity of gut microbiota, reduces systemic drug exposure, and improves the therapeutic efficacy in a rat acute colitis model compared with the oral administration of the same amount of drug in solution form. We suggest that the nanoparticle-assembled coacervate provides a promising drug delivery platform for management and treatment of numerous gastrointestinal diseases where controlled drug release with extended residence time is desired.

Date: 2021
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/s41467-021-27463-6 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-27463-6

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-021-27463-6

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().