Theranostic near-infrared-IIb emitting nanoprobes for promoting immunogenic radiotherapy and abscopal effects against cancer metastasis

Hao Li, Meng Wang, Biao Huang, Su-Wen Zhu, Jun-Jie Zhou, Chen De-Run, Ran Cui (), Mingxi Zhang () and Zhi-Jun Sun ()
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Hao Li: Wuhan University
Meng Wang: Wuhan University of Technology
Biao Huang: Wuhan University
Su-Wen Zhu: Wuhan University
Jun-Jie Zhou: Wuhan University
Chen De-Run: Wuhan University
Ran Cui: Wuhan University
Mingxi Zhang: Wuhan University of Technology
Zhi-Jun Sun: Wuhan University

Nature Communications, 2021, vol. 12, issue 1, 1-17

Abstract: Abstract Radiotherapy is an important therapeutic strategy for cancer treatment through direct damage to cancer cells and augmentation of antitumor immune responses. However, the efficacy of radiotherapy is limited by hypoxia-mediated radioresistance and immunosuppression in tumor microenvironment. Here, we construct a stabilized theranostic nanoprobe based on quantum dots emitting in the near-infrared IIb (NIR-IIb, 1,500–1,700 nm) window modified by catalase, arginine–glycine–aspartate peptides and poly(ethylene glycol). We demonstrate that the nanoprobes effectively aggregate in the tumor site to locate the tumor region, thereby realizing precision radiotherapy with few side-effects. In addition, nanoprobes relieve intratumoral hypoxia and reduce the tumor infiltration of immunosuppressive cells. Moreover, the nanoprobes promote the immunogenic cell death of cancer cells to trigger the activation of dendritic cells and enhance T cell-mediated antitumor immunity to inhibit tumor metastasis. Collectively, the nanoprobe-mediated immunogenic radiotherapy can boost the abscopal effect to inhibit tumor metastasis and prolong survival.

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-27485-0

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DOI: 10.1038/s41467-021-27485-0

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