Polygenic contribution to the relationship of loneliness and social isolation with schizophrenia

Álvaro Andreu-Bernabeu, Covadonga M. Díaz-Caneja, Javier Costas, Lucía De Hoyos, Carol Stella, Xaquín Gurriarán, Clara Alloza, Lourdes Fañanás, Julio Bobes, Ana González-Pinto, Benedicto Crespo-Facorro, Lourdes Martorell, Elisabet Vilella, Gerard Muntané, Juan Nacher, María Dolores Molto, Eduardo Jesús Aguilar, Mara Parellada, Celso Arango and Javier González-Peñas ()
Additional contact information
Álvaro Andreu-Bernabeu: Hospital General Universitario Gregorio Marañón
Covadonga M. Díaz-Caneja: Hospital General Universitario Gregorio Marañón
Javier Costas: Instituto de Investigación Sanitaria (IDIS) de Santiago de Compostela, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), Servizo Galego de Saúde (SERGAS), Santiago de Compostela
Lucía De Hoyos: Hospital General Universitario Gregorio Marañón
Carol Stella: Hospital General Universitario Gregorio Marañón
Xaquín Gurriarán: Hospital General Universitario Gregorio Marañón
Clara Alloza: Hospital General Universitario Gregorio Marañón
Lourdes Fañanás: CIBERSAM, Centro Investigación Biomédica en Red Salud Mental
Julio Bobes: CIBERSAM, Centro Investigación Biomédica en Red Salud Mental
Ana González-Pinto: CIBERSAM, Centro Investigación Biomédica en Red Salud Mental
Benedicto Crespo-Facorro: CIBERSAM, Centro Investigación Biomédica en Red Salud Mental
Lourdes Martorell: CIBERSAM, Centro Investigación Biomédica en Red Salud Mental
Elisabet Vilella: CIBERSAM, Centro Investigación Biomédica en Red Salud Mental
Gerard Muntané: CIBERSAM, Centro Investigación Biomédica en Red Salud Mental
Juan Nacher: CIBERSAM, Centro Investigación Biomédica en Red Salud Mental
María Dolores Molto: CIBERSAM, Centro Investigación Biomédica en Red Salud Mental
Eduardo Jesús Aguilar: CIBERSAM, Centro Investigación Biomédica en Red Salud Mental
Mara Parellada: Hospital General Universitario Gregorio Marañón
Celso Arango: Hospital General Universitario Gregorio Marañón
Javier González-Peñas: Hospital General Universitario Gregorio Marañón

Nature Communications, 2022, vol. 13, issue 1, 1-11

Abstract: Abstract Previous research suggests an association of loneliness and social isolation (LNL-ISO) with schizophrenia. Here, we demonstrate a LNL-ISO polygenic score contribution to schizophrenia risk in an independent case-control sample (N = 3,488). We then subset schizophrenia predisposing variation based on its effect on LNL-ISO. We find that genetic variation with concordant effects in both phenotypes shows significant SNP-based heritability enrichment, higher polygenic contribution in females, and positive covariance with mental disorders such as depression, anxiety, attention-deficit hyperactivity disorder, alcohol dependence, and autism. Conversely, genetic variation with discordant effects only contributes to schizophrenia risk in males and is negatively correlated with those disorders. Mendelian randomization analyses demonstrate a plausible bi-directional causal relationship between LNL-ISO and schizophrenia, with a greater effect of LNL-ISO liability on schizophrenia than vice versa. These results illustrate the genetic footprint of LNL-ISO on schizophrenia.

Date: 2022
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-021-27598-6 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-021-27598-6

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-021-27598-6

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().