Synthetic recovery of impulse propagation in myocardial infarction via silicon carbide semiconductive nanowires

Paola Lagonegro, Stefano Rossi, Nicolò Salvarani, Francesco Paolo Lo Muzio, Giacomo Rozzi, Jessica Modica, Franca Bigi, Martina Quaretti, Giancarlo Salviati, Silvana Pinelli, Rossella Alinovi, Daniele Catalucci, Francesca D’Autilia, Ferdinando Gazza, Gianluigi Condorelli, Francesca Rossi and Michele Miragoli ()
Additional contact information
Paola Lagonegro: Istituto dei Materiali per l’Elettronica e il Magnetismo (IMEM), National Research Council CNR
Stefano Rossi: CERT, Centro di Eccellenza per la Ricerca Tossicologica, Dipartimento di Medicina e Chirurgia Università di Parma
Nicolò Salvarani: Humanitas Research Hospital — IRCCS, Via Manzoni 56
Francesco Paolo Lo Muzio: CERT, Centro di Eccellenza per la Ricerca Tossicologica, Dipartimento di Medicina e Chirurgia Università di Parma
Giacomo Rozzi: CERT, Centro di Eccellenza per la Ricerca Tossicologica, Dipartimento di Medicina e Chirurgia Università di Parma
Jessica Modica: Humanitas Research Hospital — IRCCS, Via Manzoni 56
Franca Bigi: Istituto dei Materiali per l’Elettronica e il Magnetismo (IMEM), National Research Council CNR
Martina Quaretti: Istituto dei Materiali per l’Elettronica e il Magnetismo (IMEM), National Research Council CNR
Giancarlo Salviati: Istituto dei Materiali per l’Elettronica e il Magnetismo (IMEM), National Research Council CNR
Silvana Pinelli: CERT, Centro di Eccellenza per la Ricerca Tossicologica, Dipartimento di Medicina e Chirurgia Università di Parma
Rossella Alinovi: CERT, Centro di Eccellenza per la Ricerca Tossicologica, Dipartimento di Medicina e Chirurgia Università di Parma
Daniele Catalucci: Humanitas Research Hospital — IRCCS, Via Manzoni 56
Francesca D’Autilia: Humanitas Research Hospital — IRCCS, Via Manzoni 56
Ferdinando Gazza: Dipartimento di Scienze Medico-Veterinarie
Gianluigi Condorelli: Humanitas Research Hospital — IRCCS, Via Manzoni 56
Francesca Rossi: Istituto dei Materiali per l’Elettronica e il Magnetismo (IMEM), National Research Council CNR
Michele Miragoli: CERT, Centro di Eccellenza per la Ricerca Tossicologica, Dipartimento di Medicina e Chirurgia Università di Parma

Nature Communications, 2022, vol. 13, issue 1, 1-13

Abstract: Abstract Myocardial infarction causes 7.3 million deaths worldwide, mostly for fibrillation that electrically originates from the damaged areas of the left ventricle. Conventional cardiac bypass graft and percutaneous coronary interventions allow reperfusion of the downstream tissue but do not counteract the bioelectrical alteration originated from the infarct area. Genetic, cellular, and tissue engineering therapies are promising avenues but require days/months for permitting proper functional tissue regeneration. Here we engineered biocompatible silicon carbide semiconductive nanowires that synthetically couple, via membrane nanobridge formations, isolated beating cardiomyocytes over distance, restoring physiological cell-cell conductance, thereby permitting the synchronization of bioelectrical activity in otherwise uncoupled cells. Local in-situ multiple injections of nanowires in the left ventricular infarcted regions allow rapid reinstatement of impulse propagation across damaged areas and recover electrogram parameters and conduction velocity. Here we propose this nanomedical intervention as a strategy for reducing ventricular arrhythmia after acute myocardial infarction.

Date: 2022
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-021-27637-2 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-021-27637-2

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-021-27637-2

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().