Interfacial-confined coordination to single-atom nanotherapeutics

Limei Qin, Jie Gan, Dechao Niu (), Yueqiang Cao, Xuezhi Duan (), Xing Qin, Hao Zhang, Zheng Jiang, Yongjun Jiang, Sheng Dai, Yongsheng Li () and Jianlin Shi
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Limei Qin: East China University of Science and Technology
Jie Gan: East China University of Science and Technology
Dechao Niu: East China University of Science and Technology
Yueqiang Cao: East China University of Science and Technology
Xuezhi Duan: East China University of Science and Technology
Xing Qin: East China University of Science and Technology
Hao Zhang: Shanghai Advanced Research Institute, Chinese Academy of Sciences
Zheng Jiang: Shanghai Advanced Research Institute, Chinese Academy of Sciences
Yongjun Jiang: East China University of Science and Technology
Sheng Dai: East China University of Science and Technology
Yongsheng Li: East China University of Science and Technology
Jianlin Shi: East China University of Science and Technology

Nature Communications, 2022, vol. 13, issue 1, 1-12

Abstract: Abstract Pursuing and developing effective methodologies to construct highly active catalytic sites to maximize the atomic and energy efficiency by material engineering are attractive. Relative to the tremendous researches of carbon-based single atom systems, the construction of bio-applicable single atom materials is still in its infancy. Herein, we propose a facile and general interfacial-confined coordination strategy to construct high-quality single-atom nanotherapeutic agent with Fe single atoms being anchored on defective carbon dots confined in a biocompatible mesoporous silica nanoreactor. Furthermore, the efficient energy conversion capability of silica-based Fe single atoms system has been demonstrated on the basis of the exogenous physical photo irradiation and endogenous biochemical reactive oxygen species stimulus in the confined mesoporous network. More importantly, the highest photothermal conversion efficiency with the mechanism of increased electron density and narrow bandgap of this single atom structure in defective carbon was proposed by the theoretical DFT calculations. The present methodology provides a scientific paradigm to design and develop versatile single atom nanotherapeutics with adjustable metal components and tune the corresponding reactions for safe and efficient tumor therapeutic strategy.

Date: 2022
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DOI: 10.1038/s41467-021-27640-7

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