Combination of pre-adapted bacteriophage therapy and antibiotics for treatment of fracture-related infection due to pandrug-resistant Klebsiella pneumoniae

Anaïs Eskenazi (), Cédric Lood, Julia Wubbolts, Maya Hites, Nana Balarjishvili, Lika Leshkasheli, Lia Askilashvili, Leila Kvachadze, Vera Noort, Jeroen Wagemans, Marc Jayankura, Nina Chanishvili, Mark Boer, Peter Nibbering, Mzia Kutateladze, Rob Lavigne, Maya Merabishvili and Jean-Paul Pirnay
Additional contact information
Anaïs Eskenazi: CUB-Erasme Hospital
Cédric Lood: KU Leuven
Julia Wubbolts: Leiden University Medical Centre
Maya Hites: CUB-Erasme Hospital
Nana Balarjishvili: Microbiology and Virology
Lika Leshkasheli: Microbiology and Virology
Lia Askilashvili: Microbiology and Virology
Leila Kvachadze: Microbiology and Virology
Vera Noort: KU Leuven
Jeroen Wagemans: KU Leuven
Marc Jayankura: CUB-Erasme Hospital
Nina Chanishvili: Microbiology and Virology
Mark Boer: Leiden University Medical Centre
Peter Nibbering: Leiden University Medical Centre
Mzia Kutateladze: Microbiology and Virology
Rob Lavigne: KU Leuven
Maya Merabishvili: Queen Astrid Military Hospital
Jean-Paul Pirnay: Queen Astrid Military Hospital

Nature Communications, 2022, vol. 13, issue 1, 1-14

Abstract: Abstract A 30-year-old bombing victim with a fracture-related pandrug-resistant Klebsiella pneumoniae infection after long-term (>700 days) antibiotic therapy is treated with a pre-adapted bacteriophage along with meropenem and colistin, followed by ceftazidime/avibactam. This salvage therapy results in objective clinical, microbiological and radiological improvement of the patient’s wounds and overall condition. In support, the bacteriophage and antibiotic combination is highly effective against the patient’s K. pneumoniae strain in vitro, in 7-day mature biofilms and in suspensions.

Date: 2022
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DOI: 10.1038/s41467-021-27656-z

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