Temperature sensitivity of Notch signaling underlies species-specific developmental plasticity and robustness in amniote brains

Tadashi Nomura (), Kohjiro Nagao, Ryo Shirai, Hitoshi Gotoh, Masato Umeda and Katsuhiko Ono
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Tadashi Nomura: Kyoto Prefectural University of Medicine, INAMORI Memorial Building
Kohjiro Nagao: Kyoto University, Katsura
Ryo Shirai: Niigata University
Hitoshi Gotoh: Kyoto Prefectural University of Medicine, INAMORI Memorial Building
Masato Umeda: Kyoto University, Katsura
Katsuhiko Ono: Kyoto Prefectural University of Medicine, INAMORI Memorial Building

Nature Communications, 2022, vol. 13, issue 1, 1-14

Abstract: Abstract Ambient temperature significantly affects developmental timing in animals. The temperature sensitivity of embryogenesis is generally believed to be a consequence of the thermal dependency of cellular metabolism. However, the adaptive molecular mechanisms that respond to variations in temperature remain unclear. Here, we report species-specific thermal sensitivity of Notch signaling in the developing amniote brain. Transient hypothermic conditions increase canonical Notch activity and reduce neurogenesis in chick neural progenitors. Increased biosynthesis of phosphatidylethanolamine, a major glycerophospholipid components of the plasma membrane, mediates hypothermia-induced Notch activation. Furthermore, the species-specific thermal dependency of Notch signaling is associated with developmental robustness to altered Notch signaling. Our results reveal unique regulatory mechanisms for temperature-dependent neurogenic potentials that underlie developmental and evolutionary adaptations to a range of ambient temperatures in amniotes.

Date: 2022
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DOI: 10.1038/s41467-021-27707-5

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