Chirality transmission in macromolecular domains

Shankar Pandey, Shankar Mandal, Mathias Bogetoft Danielsen, Asha Brown, Changpeng Hu, Niels Johan Christensen, Alina Vitaliyivna Kulakova, Shixi Song, Tom Brown, Knud J. Jensen, Jesper Wengel, Chenguang Lou () and Hanbin Mao ()
Additional contact information
Shankar Pandey: Kent State University
Shankar Mandal: Kent State University
Mathias Bogetoft Danielsen: University of Southern Denmark
Asha Brown: ATDBio Ltd., Magdalen Centre, Oxford Science Park
Changpeng Hu: Kent State University
Niels Johan Christensen: University of Copenhagen
Alina Vitaliyivna Kulakova: University of Copenhagen
Shixi Song: University of Southern Denmark
Tom Brown: University of Oxford
Knud J. Jensen: University of Copenhagen
Jesper Wengel: University of Southern Denmark
Chenguang Lou: University of Southern Denmark
Hanbin Mao: Kent State University

Nature Communications, 2022, vol. 13, issue 1, 1-11

Abstract: Abstract Chiral communications exist in secondary structures of foldamers and copolymers via a network of noncovalent interactions within effective intermolecular force (IMF) range. It is not known whether long-range chiral communication exists between macromolecular tertiary structures such as peptide coiled-coils beyond the IMF distance. Harnessing the high sensitivity of single-molecule force spectroscopy, we investigate the chiral interaction between covalently linked DNA duplexes and peptide coiled-coils by evaluating the binding of a diastereomeric pair of three DNA-peptide conjugates. We find that right-handed DNA triple helices well accommodate peptide triple coiled-coils of the same handedness, but not with the left-handed coiled-coil stereoisomers. This chiral communication is effective in a range (

Date: 2022
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DOI: 10.1038/s41467-021-27708-4

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