Engineering shape memory and morphing protein hydrogels based on protein unfolding and folding

Qingyuan Bian, Linglan Fu and Hongbin Li ()
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Qingyuan Bian: University of British Columbia
Linglan Fu: University of British Columbia
Hongbin Li: University of British Columbia

Nature Communications, 2022, vol. 13, issue 1, 1-8

Abstract: Abstract Engineering shape memory/morphing materials have achieved considerable progress in polymer-based systems with broad potential applications. However, engineering protein-based shape memory/morphing materials remains challenging and under-explored. Here we report the design of a bilayer protein-based shape memory/morphing hydrogel based on protein folding-unfolding mechanism. We fabricate the protein-bilayer structure using two tandem modular elastomeric proteins (GB1)8 and (FL)8. Both protein layers display distinct denaturant-dependent swelling profiles and Young’s moduli. Due to such protein unfolding-folding induced changes in swelling, the bilayer hydrogels display highly tunable and reversible bidirectional bending deformation depending upon the denaturant concentration and layer geometry. Based on these programmable and reversible bending behaviors, we further utilize the protein-bilayer structure as hinge to realize one-dimensional to two-dimensional and two-dimensional to three-dimensional folding transformations of patterned hydrogels. The present work will offer new inspirations for the design and fabrication of novel shape morphing materials.

Date: 2022
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DOI: 10.1038/s41467-021-27744-0

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