Yeast-derived nanoparticles remodel the immunosuppressive microenvironment in tumor and tumor-draining lymph nodes to suppress tumor growth

Jialu Xu, Qingle Ma, Yue Zhang, Ziying Fei, Yifei Sun, Qin Fan, Bo Liu, Jinyu Bai, Yue Yu, Jianhong Chu (), Jingrun Chen () and Chao Wang ()
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Jialu Xu: Soochow University
Qingle Ma: Soochow University
Yue Zhang: Soochow University
Ziying Fei: Soochow University
Yifei Sun: Soochow University
Qin Fan: Soochow University
Bo Liu: Soochow University
Jinyu Bai: The Second Affiliated Hospital of Soochow University
Yue Yu: Soochow University
Jianhong Chu: The First Affiliated Hospital of Soochow University, Institute of Blood and Marrow Transplantation of Soochow University
Jingrun Chen: Soochow University
Chao Wang: Soochow University

Nature Communications, 2022, vol. 13, issue 1, 1-15

Abstract: Abstract Microbe-based cancer immunotherapy has recently emerged as a hot topic for cancer treatment. However, serious limitations remain including infection associated side-effect and unsatisfactory outcomes in clinic trials. Here, we fabricate different sizes of nano-formulations derived from yeast cell wall (YCW NPs) by differential centrifugation. The induction of anticancer immunity of our formulations appears to inversely correlate with their size due to the ability to accumulate in tumor-draining lymph node (TDLN). Moreover, we use a percolation model to explain their distribution behavior toward TDLN. The abundance and functional orientation of each effector component are significantly improved not only in the microenvironment in tumor but also in the TDLN following small size YCW NPs treatment. In combination with programmed death-ligand 1 (PD-L1) blockade, we demonstrate anticancer efficiency in melanoma-challenged mice. We delineate potential strategy to target immunosuppressive microenvironment by microbe-based nanoparticles and highlight the role of size effect in microbe-based immune therapeutics.

Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-021-27750-2

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DOI: 10.1038/s41467-021-27750-2

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