DNA methylation aging and transcriptomic studies in horses

Steve Horvath (), Amin Haghani, Sichong Peng, Erin N. Hales, Joseph A. Zoller, Ken Raj, Brenda Larison, Todd R. Robeck, Jessica L. Petersen, Rebecca R. Bellone and Carrie J. Finno ()
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Steve Horvath: University of California, Los Angeles
Amin Haghani: University of California, Los Angeles
Sichong Peng: Davis School of Veterinary Medicine
Erin N. Hales: Davis School of Veterinary Medicine
Joseph A. Zoller: University of California, Los Angeles
Ken Raj: Public Health England
Brenda Larison: University of California
Todd R. Robeck: SeaWorld Parks and Entertainment
Jessica L. Petersen: University of Nebraska
Rebecca R. Bellone: Davis School of Veterinary Medicine
Carrie J. Finno: Davis School of Veterinary Medicine

Nature Communications, 2022, vol. 13, issue 1, 1-13

Abstract: Abstract Cytosine methylation patterns have not yet been thoroughly studied in horses. Here, we profile n = 333 samples from 42 horse tissue types at loci that are highly conserved between mammalian species using a custom array (HorvathMammalMethylChip40). Using the blood and liver tissues from horses, we develop five epigenetic aging clocks: a multi-tissue clock, a blood clock, a liver clock and two dual-species clocks that apply to both horses and humans. In addition, using blood methylation data from three additional equid species (plains zebra, Grevy’s zebras and Somali asses), we develop another clock that applies across all equid species. Castration does not significantly impact the epigenetic aging rate of blood or liver samples from horses. Methylation and RNA data from the same tissues define the relationship between methylation and RNA expression across horse tissues. We expect that the multi-tissue atlas will become a valuable resource.

Date: 2022
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DOI: 10.1038/s41467-021-27754-y

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