A cortical cell ensemble in the posterior parietal cortex controls past experience-dependent memory updating

Akinobu Suzuki, Sakurako Kosugi, Emi Murayama, Eri Sasakawa, Noriaki Ohkawa, Ayumu Konno, Hirokazu Hirai and Kaoru Inokuchi ()
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Akinobu Suzuki: University of Toyama
Sakurako Kosugi: University of Toyama
Emi Murayama: University of Toyama
Eri Sasakawa: University of Toyama
Noriaki Ohkawa: University of Toyama
Ayumu Konno: Gunma University Graduate School of Medicine
Hirokazu Hirai: Gunma University Graduate School of Medicine
Kaoru Inokuchi: University of Toyama

Nature Communications, 2022, vol. 13, issue 1, 1-14

Abstract: Abstract When processing current sensory inputs, animals refer to related past experiences. Current information is then incorporated into the related neural network to update previously stored memories. However, the neuronal mechanism underlying the impact of memories of prior experiences on current learning is not well understood. Here, we found that a cellular ensemble in the posterior parietal cortex (PPC) that is activated during past experience mediates an interaction between past and current information to update memory through a PPC-anterior cingulate cortex circuit in mice. Moreover, optogenetic silencing of the PPC ensemble immediately after retrieval dissociated the interaction without affecting individual memories stored in the hippocampus and amygdala. Thus, a specific subpopulation of PPC cells represents past information and instructs downstream brain regions to update previous memories.

Date: 2022
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DOI: 10.1038/s41467-021-27763-x

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