A pandemic-enabled comparison of discovery platforms demonstrates a naïve antibody library can match the best immune-sourced antibodies

Fortunato Ferrara, M. Frank Erasmus, Sara D’Angelo, Camila Leal-Lopes, André A. Teixeira, Alok Choudhary, William Honnen, David Calianese, Deli Huang, Linghan Peng, James E. Voss, David Nemazee, Dennis R. Burton, Abraham Pinter and Andrew R. M. Bradbury ()
Additional contact information
Fortunato Ferrara: Specifica Inc
M. Frank Erasmus: Specifica Inc
Sara D’Angelo: Specifica Inc
Camila Leal-Lopes: New Mexico Consortium
André A. Teixeira: New Mexico Consortium
Alok Choudhary: Rutgers, The State University of New Jersey
William Honnen: Rutgers, The State University of New Jersey
David Calianese: Rutgers, The State University of New Jersey
Deli Huang: Zhejiang University
Linghan Peng: The Scripps Research Institute
James E. Voss: The Scripps Research Institute
David Nemazee: The Scripps Research Institute
Dennis R. Burton: The Scripps Research Institute
Abraham Pinter: Rutgers, The State University of New Jersey
Andrew R. M. Bradbury: Specifica Inc

Nature Communications, 2022, vol. 13, issue 1, 1-12

Abstract: Abstract As a result of the SARS-CoV-2 pandemic numerous scientific groups have generated antibodies against a single target: the CoV-2 spike antigen. This has provided an unprecedented opportunity to compare the efficacy of different methods and the specificities and qualities of the antibodies generated by those methods. Generally, the most potent neutralizing antibodies have been generated from convalescent patients and immunized animals, with non-immune phage libraries usually yielding significantly less potent antibodies. Here, we show that it is possible to generate ultra-potent (IC50

Date: 2022
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DOI: 10.1038/s41467-021-27799-z

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