Distinct kinetics of antibodies to 111 Plasmodium falciparum proteins identifies markers of recent malaria exposure

Victor Yman (), James Tuju, Michael T. White, Gathoni Kamuyu, Kennedy Mwai, Nelson Kibinge, Muhammad Asghar, Christopher Sundling, Klara Sondén, Linda Murungi, Daniel Kiboi, Rinter Kimathi, Timothy Chege, Emily Chepsat, Patience Kiyuka, Lydia Nyamako, Faith H. A. Osier and Anna Färnert
Additional contact information
Victor Yman: Karolinska Institutet
James Tuju: Centre for Geographical Medicine Research Coast
Michael T. White: Department of Parasites and Insect Vectors, Institut Pasteur
Gathoni Kamuyu: Centre for Geographical Medicine Research Coast
Kennedy Mwai: Centre for Geographical Medicine Research Coast
Nelson Kibinge: Centre for Geographical Medicine Research Coast
Muhammad Asghar: Karolinska Institutet
Christopher Sundling: Karolinska Institutet
Klara Sondén: Karolinska Institutet
Linda Murungi: Centre for Geographical Medicine Research Coast
Daniel Kiboi: Centre for Geographical Medicine Research Coast
Rinter Kimathi: Centre for Geographical Medicine Research Coast
Timothy Chege: Centre for Geographical Medicine Research Coast
Emily Chepsat: Centre for Geographical Medicine Research Coast
Patience Kiyuka: Centre for Geographical Medicine Research Coast
Lydia Nyamako: Centre for Geographical Medicine Research Coast
Faith H. A. Osier: Centre for Geographical Medicine Research Coast
Anna Färnert: Karolinska Institutet

Nature Communications, 2022, vol. 13, issue 1, 1-15

Abstract: Abstract Strengthening malaria surveillance is a key intervention needed to reduce the global disease burden. Reliable serological markers of recent malaria exposure could improve current surveillance methods by allowing for accurate estimates of infection incidence from limited data. We studied the IgG antibody response to 111 Plasmodium falciparum proteins in 65 adult travellers followed longitudinally after a natural malaria infection in complete absence of re-exposure. We identified a combination of five serological markers that detect exposure within the previous three months with >80% sensitivity and specificity. Using mathematical modelling, we examined the antibody kinetics and determined that responses informative of recent exposure display several distinct characteristics: rapid initial boosting and decay, less inter-individual variation in response kinetics, and minimal persistence over time. Such serological exposure markers could be incorporated into routine malaria surveillance to guide efforts for malaria control and elimination.

Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-021-27863-8

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DOI: 10.1038/s41467-021-27863-8

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