MyoD is a 3D genome structure organizer for muscle cell identity

Ruiting Wang, Fengling Chen, Qian Chen, Xin Wan, Minglei Shi, Antony K. Chen, Zhao Ma, Guohong Li, Min Wang, Yachen Ying, Qinyao Liu, Hu Li, Xu Zhang, Jinbiao Ma, Jiayun Zhong, Meihong Chen, Michael Q. Zhang (), Yong Zhang (), Yang Chen () and Dahai Zhu ()
Additional contact information
Ruiting Wang: Peking Union Medical College
Fengling Chen: Tsinghua University
Qian Chen: Peking Union Medical College
Xin Wan: Peking Union Medical College
Minglei Shi: Tsinghua University
Antony K. Chen: Peking University
Zhao Ma: Peking University
Guohong Li: Chinese Academy of Sciences
Min Wang: Chinese Academy of Sciences
Yachen Ying: Peking University
Qinyao Liu: Peking Union Medical College
Hu Li: Peking Union Medical College
Xu Zhang: Beijing institute of collaborative innovation
Jinbiao Ma: Fudan University
Jiayun Zhong: Fudan University
Meihong Chen: Peking Union Medical College
Michael Q. Zhang: Tsinghua University
Yong Zhang: Peking Union Medical College
Yang Chen: Peking Union Medical College
Dahai Zhu: Peking Union Medical College

Nature Communications, 2022, vol. 13, issue 1, 1-17

Abstract: Abstract The genome exists as an organized, three-dimensional (3D) dynamic architecture, and each cell type has a unique 3D genome organization that determines its cell identity. An unresolved question is how cell type-specific 3D genome structures are established during development. Here, we analyzed 3D genome structures in muscle cells from mice lacking the muscle lineage transcription factor (TF), MyoD, versus wild-type mice. We show that MyoD functions as a “genome organizer” that specifies 3D genome architecture unique to muscle cell development, and that H3K27ac is insufficient for the establishment of MyoD-induced chromatin loops in muscle cells. Moreover, we present evidence that other cell lineage-specific TFs might also exert functional roles in orchestrating lineage-specific 3D genome organization during development.

Date: 2022
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DOI: 10.1038/s41467-021-27865-6

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