Non-invasive MR imaging of human brain lymphatic networks with connections to cervical lymph nodes

Mehmet Sait Albayram (), Garrett Smith, Fatih Tufan, Ibrahim Sacit Tuna, Mehmet Bostancıklıoğlu, Michael Zile and Onder Albayram
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Mehmet Sait Albayram: University of Florida, College of Medicine
Garrett Smith: University of Florida, College of Medicine
Fatih Tufan: Geriatrician (PP), Silivrikapi Mh. Hisaralti Cd
Ibrahim Sacit Tuna: University of Florida, College of Medicine
Mehmet Bostancıklıoğlu: Elysium Health Center
Michael Zile: Medical University of South Carolina
Onder Albayram: Medical University of South Carolina

Nature Communications, 2022, vol. 13, issue 1, 1-14

Abstract: Abstract Meningeal lymphatic vessels have been described in animal studies, but limited comparable data is available in human studies. Here we show dural lymphatic structures along the dural venous sinuses in dorsal regions and along cranial nerves in the ventral regions in the human brain. 3D T2-Fluid Attenuated Inversion Recovery magnetic resonance imaging relies on internal signals of protein rich lymphatic fluid rather than contrast media and is used in the present study to visualize the major human dural lymphatic structures. Moreover we detect direct connections between lymphatic fluid channels along the cranial nerves and vascular structures and the cervical lymph nodes. We also identify age-related cervical lymph node atrophy and thickening of lymphatics channels in both dorsal and ventral regions, findings which reflect the reduced lymphatic output of the aged brain.

Date: 2022
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DOI: 10.1038/s41467-021-27887-0

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