Reduced infant rhesus macaque growth rates due to environmental enteric dysfunction and association with histopathology in the large intestine

Sara M. Hendrickson, Archana Thomas, Kamm Prongay, Andrew J. Haertel, Laura M. Garzel, Leanne Gill, Tasha Barr, Nicholas S. Rhoades, Rachel Reader, Mark Galan, Julie M. Carroll, Charles T. Roberts, Lina Gao, Ian J. Amanna, Ilhem Messaoudi and Mark K. Slifka ()
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Sara M. Hendrickson: Oregon Health & Science University
Archana Thomas: Oregon Health & Science University
Kamm Prongay: Oregon Health & Science University
Andrew J. Haertel: Oregon Health & Science University
Laura M. Garzel: University of California, Davis
Leanne Gill: University of California, Davis
Tasha Barr: University of California Irvine
Nicholas S. Rhoades: University of California Irvine
Rachel Reader: University of California, Davis
Mark Galan: Rutgers, New Jersey Medical School
Julie M. Carroll: Oregon Health & Science University
Charles T. Roberts: Oregon Health & Science University
Lina Gao: Knight Cancer Institute
Ian J. Amanna: Najít Technologies, Inc.
Ilhem Messaoudi: University of California Irvine
Mark K. Slifka: Oregon Health & Science University

Nature Communications, 2022, vol. 13, issue 1, 1-13

Abstract: Abstract Environmental enteric dysfunction is associated with malnutrition as well as infant growth stunting and has been classically defined by villous blunting, decreased crypt-to-villus ratio, and inflammation in the small intestine. Here, we characterized environmental enteric dysfunction among infant rhesus macaques that are naturally exposed to enteric pathogens commonly linked to human growth stunting. Remarkably, despite villous atrophy and histological abnormalities observed in the small intestine, poor growth trajectories and low serum tryptophan levels were correlated with increased histopathology in the large intestine. This work provides insight into the mechanisms underlying this disease and indicates that the large intestine may be an important target for therapeutic intervention.

Date: 2022
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DOI: 10.1038/s41467-021-27925-x

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