Cerebellar connectivity maps embody individual adaptive behavior in mice

Ludovic Spaeth, Jyotika Bahuguna, Theo Gagneux, Kevin Dorgans, Izumi Sugihara, Bernard Poulain, Demian Battaglia and Philippe Isope ()
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Ludovic Spaeth: Université de Strasbourg
Jyotika Bahuguna: Aix-Marseille Université, Institut de Neurosciences des Systèmes, CNRS
Theo Gagneux: Université de Strasbourg
Kevin Dorgans: Université de Strasbourg
Izumi Sugihara: Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences
Bernard Poulain: Université de Strasbourg
Demian Battaglia: Aix-Marseille Université, Institut de Neurosciences des Systèmes, CNRS
Philippe Isope: Université de Strasbourg

Nature Communications, 2022, vol. 13, issue 1, 1-19

Abstract: Abstract The cerebellar cortex encodes sensorimotor adaptation during skilled locomotor behaviors, however the precise relationship between synaptic connectivity and behavior is unclear. We studied synaptic connectivity between granule cells (GCs) and Purkinje cells (PCs) in murine acute cerebellar slices using photostimulation of caged glutamate combined with patch-clamp in developing or after mice adapted to different locomotor contexts. By translating individual maps into graph network entities, we found that synaptic maps in juvenile animals undergo critical period characterized by dissolution of their structure followed by the re-establishment of a patchy functional organization in adults. Although, in adapted mice, subdivisions in anatomical microzones do not fully account for the observed spatial map organization in relation to behavior, we can discriminate locomotor contexts with high accuracy. We also demonstrate that the variability observed in connectivity maps directly accounts for motor behavior traits at the individual level. Our findings suggest that, beyond general motor contexts, GC-PC networks also encode internal models underlying individual-specific motor adaptation.

Date: 2022
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DOI: 10.1038/s41467-022-27984-8

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