Hippocampal ensembles represent sequential relationships among an extended sequence of nonspatial events

Babak Shahbaba, Lingge Li, Forest Agostinelli, Mansi Saraf, Keiland W. Cooper, Derenik Haghverdian, Gabriel A. Elias, Pierre Baldi and Norbert J. Fortin ()
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Babak Shahbaba: University of California
Lingge Li: University of California
Forest Agostinelli: University of California
Mansi Saraf: University of California
Keiland W. Cooper: University of California
Derenik Haghverdian: University of California
Gabriel A. Elias: University of California
Pierre Baldi: University of California
Norbert J. Fortin: University of California

Nature Communications, 2022, vol. 13, issue 1, 1-17

Abstract: Abstract The hippocampus is critical to the temporal organization of our experiences. Although this fundamental capacity is conserved across modalities and species, its underlying neuronal mechanisms remain unclear. Here we recorded hippocampal activity as rats remembered an extended sequence of nonspatial events unfolding over several seconds, as in daily life episodes in humans. We then developed statistical machine learning methods to analyze the ensemble activity and discovered forms of sequential organization and coding important for order memory judgments. Specifically, we found that hippocampal ensembles provide significant temporal coding throughout nonspatial event sequences, differentiate distinct types of task-critical information sequentially within events, and exhibit theta-associated reactivation of the sequential relationships among events. We also demonstrate that nonspatial event representations are sequentially organized within individual theta cycles and precess across successive cycles. These findings suggest a fundamental function of the hippocampal network is to encode, preserve, and predict the sequential order of experiences.

Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-28057-6

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DOI: 10.1038/s41467-022-28057-6

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