Pickering emulsion droplet-based biomimetic microreactors for continuous flow cascade reactions

Ming Zhang, Rammile Ettelaie, Lianlian Dong, Xiaolong Li, Ting Li, Xiaoming Zhang, Bernard P. Binks and Hengquan Yang ()
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Ming Zhang: Shanxi University
Rammile Ettelaie: University of Leeds
Lianlian Dong: Shanxi University
Xiaolong Li: Shanxi University
Ting Li: Shanxi University
Xiaoming Zhang: Shanxi University
Bernard P. Binks: University of Hull
Hengquan Yang: Shanxi University

Nature Communications, 2022, vol. 13, issue 1, 1-11

Abstract: Abstract A continuous flow cascade of multi-step catalytic reactions is a cutting-edge concept to revolutionize stepwise catalytic synthesis yet is still challenging in practical applications. Herein, a method for practical one-pot cascade catalysis is developed by combining Pickering emulsions with continuous flow. Our method involves co-localization of different catalytically active sub-compartments within droplets of a Pickering emulsion yielding cell-like microreactors, which can be packed in a column reactor for continuous flow cascade catalysis. As exemplified by two chemo-enzymatic cascade reactions for the synthesis of chiral cyanohydrins and chiral ester, 5 − 420 fold enhancement in the catalysis efficiency and as high as 99% enantioselectivity were obtained even over a period of 80 − 240 h. The compartmentalization effect and enriching-reactant properties arising from the biomimetic microreactor are theoretically and experimentally identified as the key factors for boosting the catalysis efficiency and for regulating the kinetics of cascade catalysis.

Date: 2022
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DOI: 10.1038/s41467-022-28100-6

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