Lima1 mediates the pluripotency control of membrane dynamics and cellular metabolism

Binyamin Duethorn, Fabian Groll, Bettina Rieger, Hannes C. A. Drexler, Heike Brinkmann, Ludmila Kremer, Martin Stehling, Marie-Theres Borowski, Karina Mildner, Dagmar Zeuschner, Magdalena Zernicka-Goetz, Marc P. Stemmler, Karin B. Busch, Juan M. Vaquerizas and Ivan Bedzhov ()
Additional contact information
Binyamin Duethorn: Max Planck Institute for Molecular Biomedicine
Fabian Groll: Max Planck Institute for Molecular Biomedicine
Bettina Rieger: Institut für Integrative Zellbiologie und Physiologie, University of Münster
Hannes C. A. Drexler: Max Planck Institute for Molecular Biomedicine
Heike Brinkmann: Max Planck Institute for Molecular Biomedicine
Ludmila Kremer: Max Planck Institute for Molecular Biomedicine
Martin Stehling: Max Planck Institute for Molecular Biomedicine
Marie-Theres Borowski: Institut für Integrative Zellbiologie und Physiologie, University of Münster
Karina Mildner: Max Planck Institute for Molecular Biomedicine
Dagmar Zeuschner: Max Planck Institute for Molecular Biomedicine
Magdalena Zernicka-Goetz: University of Cambridge
Marc P. Stemmler: FAU University Erlangen-Nürnberg
Karin B. Busch: Institut für Integrative Zellbiologie und Physiologie, University of Münster
Juan M. Vaquerizas: Max Planck Institute for Molecular Biomedicine
Ivan Bedzhov: Max Planck Institute for Molecular Biomedicine

Nature Communications, 2022, vol. 13, issue 1, 1-19

Abstract: Abstract Lima1 is an extensively studied prognostic marker of malignancy and is also considered to be a tumour suppressor, but its role in a developmental context of non-transformed cells is poorly understood. Here, we characterise the expression pattern and examined the function of Lima1 in mouse embryos and pluripotent stem cell lines. We identify that Lima1 expression is controlled by the naïve pluripotency circuit and is required for the suppression of membrane blebbing, as well as for proper mitochondrial energetics in embryonic stem cells. Moreover, forcing Lima1 expression enables primed mouse and human pluripotent stem cells to be incorporated into murine pre-implantation embryos. Thus, Lima1 is a key effector molecule that mediates the pluripotency control of membrane dynamics and cellular metabolism.

Date: 2022
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-022-28139-5 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-28139-5

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-022-28139-5

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().