Direct-laser writing for subnanometer focusing and single-molecule imaging

Simao Coelho (), Jongho Baek, James Walsh, J. Justin Gooding () and Katharina Gaus
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Simao Coelho: University of New South Wales
Jongho Baek: University of New South Wales
James Walsh: University of New South Wales
J. Justin Gooding: University of New South Wales
Katharina Gaus: University of New South Wales

Nature Communications, 2022, vol. 13, issue 1, 1-8

Abstract: Abstract Two-photon direct laser writing is an additive fabrication process that utilizes two-photon absorption of tightly focused femtosecond laser pulses to implement spatially controlled polymerization of a liquid-phase photoresist. Two-photon direct laser writing is capable of nanofabricating arbitrary three-dimensional structures with nanometer accuracy. Here, we explore direct laser writing for high-resolution optical microscopy by fabricating unique 3D optical fiducials for single-molecule tracking and 3D single-molecule localization microscopy. By having control over the position and three-dimensional architecture of the fiducials, we improve axial discrimination and demonstrate isotropic subnanometer 3D focusing (

Date: 2022
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DOI: 10.1038/s41467-022-28219-6

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