Oscillating the local milieu of polymersome interiors via single input-regulated bilayer crosslinking and permeability tuning

Guhuan Liu, Jiajia Tan, Jie Cen, Guoying Zhang, Jinming Hu () and Shiyong Liu ()
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Guhuan Liu: University of Science and Technology of China
Jiajia Tan: University of Science and Technology of China
Jie Cen: University of Science and Technology of China
Guoying Zhang: University of Science and Technology of China
Jinming Hu: University of Science and Technology of China
Shiyong Liu: University of Science and Technology of China

Nature Communications, 2022, vol. 13, issue 1, 1-12

Abstract: Abstract The unique permselectivity of cellular membranes is of crucial importance to maintain intracellular homeostasis while adapting to microenvironmental changes. Although liposomes and polymersomes have been widely engineered to mimic microstructures and functions of cells, it still remains a considerable challenge to synergize the stability and permeability of artificial cells and to imitate local milieu fluctuations. Herein, we report concurrent crosslinking and permeabilizing of pH-responsive polymersomes containing Schiff base moieties within bilayer membranes via enzyme-catalyzed acid production. Notably, this synergistic crosslinking and permeabilizing strategy allows tuning of the mesh sizes of the crosslinked bilayers with subnanometer precision, showing discriminative permeability toward maltooligosaccharides with molecular sizes of ~1.4-2.6 nm. The permselectivity of bilayer membranes enables intravesicular pH oscillation, fueled by a single input of glucose. This intravesicular pH oscillation can further drive the dissipative self-assembly of pH-sensitive dipeptides. Moreover, the permeabilization of polymersomes can be regulated by intracellular pH gradient as well, enabling the controlled release of encapsulated payloads.

Date: 2022
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DOI: 10.1038/s41467-022-28227-6

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