The gut hormone Allatostatin C/Somatostatin regulates food intake and metabolic homeostasis under nutrient stress

Olga Kubrak, Takashi Koyama, Nadja Ahrentløv, Line Jensen, Alina Malita, Muhammad T. Naseem, Mette Lassen, Stanislav Nagy, Michael J. Texada, Kenneth V. Halberg and Kim Rewitz ()
Additional contact information
Olga Kubrak: University of Copenhagen
Takashi Koyama: University of Copenhagen
Nadja Ahrentløv: University of Copenhagen
Line Jensen: University of Copenhagen
Alina Malita: University of Copenhagen
Muhammad T. Naseem: University of Copenhagen
Mette Lassen: University of Copenhagen
Stanislav Nagy: University of Copenhagen
Michael J. Texada: University of Copenhagen
Kenneth V. Halberg: University of Copenhagen
Kim Rewitz: University of Copenhagen

Nature Communications, 2022, vol. 13, issue 1, 1-17

Abstract: Abstract The intestine is a central regulator of metabolic homeostasis. Dietary inputs are absorbed through the gut, which senses their nutritional value and relays hormonal information to other organs to coordinate systemic energy balance. However, the gut-derived hormones affecting metabolic and behavioral responses are poorly defined. Here we show that the endocrine cells of the Drosophila gut sense nutrient stress through a mechanism that involves the TOR pathway and in response secrete the peptide hormone allatostatin C, a Drosophila somatostatin homolog. Gut-derived allatostatin C induces secretion of glucagon-like adipokinetic hormone to coordinate food intake and energy mobilization. Loss of gut Allatostatin C or its receptor in the adipokinetic-hormone-producing cells impairs lipid and sugar mobilization during fasting, leading to hypoglycemia. Our findings illustrate a nutrient-responsive endocrine mechanism that maintains energy homeostasis under nutrient-stress conditions, a function that is essential to health and whose failure can lead to metabolic disorders.

Date: 2022
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (5)

Downloads: (external link)
https://www.nature.com/articles/s41467-022-28268-x Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-28268-x

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-022-28268-x

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().