Circadian lipid and hepatic protein rhythms shift with a phase response curve different than melatonin

Brianne A. Kent, Shadab A. Rahman, Melissa A. St. Hilaire, Leilah K. Grant, Melanie Rüger, Charles A. Czeisler and Steven W. Lockley ()
Additional contact information
Brianne A. Kent: Brigham and Women’s Hospital
Shadab A. Rahman: Brigham and Women’s Hospital
Melissa A. St. Hilaire: Brigham and Women’s Hospital
Leilah K. Grant: Brigham and Women’s Hospital
Melanie Rüger: Brigham and Women’s Hospital
Charles A. Czeisler: Brigham and Women’s Hospital
Steven W. Lockley: Brigham and Women’s Hospital

Nature Communications, 2022, vol. 13, issue 1, 1-7

Abstract: Abstract While studies suggest that light and feeding patterns can reset circadian rhythms in various metabolites, whether these shifts follow a predictable pattern is unknown. We describe the first phase response curves (PRC) for lipids and hepatic proteins in response to combined light and food stimuli. The timing of plasma rhythms was assessed by constant routine before and after exposure to a combined 6.5-hour blue light exposure and standard meal schedule, which was systematically varied by ~20° between individuals. We find that the rhythms shift according to a PRC, with generally greater shifts for lipids and liver proteins than for melatonin. PRC timing varies relative to the stimulus, with albumin and triglyceride PRCs peaking at a time similar to melatonin whereas the cholesterol and high-density lipoprotein PRCs are offset by ~12 h. These data have important implications for treating circadian misalignment in shiftworkers who consume meals and are exposed to light around the clock.

Date: 2022
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-022-28308-6 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-28308-6

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-022-28308-6

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().