Data-informed discovery of hydrolytic nanozymes

Sirong Li, Zijun Zhou, Zuoxiu Tie, Bing Wang, Meng Ye, Lei Du, Ran Cui, Wei Liu, Cuihong Wan, Quanyi Liu, Sheng Zhao, Quan Wang, Yihong Zhang, Shuo Zhang, Huigang Zhang, Yan Du and Hui Wei ()
Additional contact information
Sirong Li: Nanjing National Laboratory of Microstructures, Jiangsu Key Laboratory of Artificial Functional Materials, Nanjing University
Zijun Zhou: Nanjing National Laboratory of Microstructures, Jiangsu Key Laboratory of Artificial Functional Materials, Nanjing University
Zuoxiu Tie: Nanjing National Laboratory of Microstructures, Jiangsu Key Laboratory of Artificial Functional Materials, Nanjing University
Bing Wang: Central China Normal University
Meng Ye: China Pharmaceutical University
Lei Du: Wuhan University
Ran Cui: Wuhan University
Wei Liu: China Pharmaceutical University
Cuihong Wan: Central China Normal University
Quanyi Liu: Changchun Institute of Applied Chemistry, Chinese Academy of Sciences
Sheng Zhao: Nanjing National Laboratory of Microstructures, Jiangsu Key Laboratory of Artificial Functional Materials, Nanjing University
Quan Wang: Nanjing National Laboratory of Microstructures, Jiangsu Key Laboratory of Artificial Functional Materials, Nanjing University
Yihong Zhang: Nanjing National Laboratory of Microstructures, Jiangsu Key Laboratory of Artificial Functional Materials, Nanjing University
Shuo Zhang: Nanjing National Laboratory of Microstructures, Jiangsu Key Laboratory of Artificial Functional Materials, Nanjing University
Huigang Zhang: Nanjing National Laboratory of Microstructures, Jiangsu Key Laboratory of Artificial Functional Materials, Nanjing University
Yan Du: Changchun Institute of Applied Chemistry, Chinese Academy of Sciences
Hui Wei: Nanjing National Laboratory of Microstructures, Jiangsu Key Laboratory of Artificial Functional Materials, Nanjing University

Nature Communications, 2022, vol. 13, issue 1, 1-12

Abstract: Abstract Nanozyme is a collection of nanomaterials with enzyme-like activity but higher environmental tolerance and long-term stability than their natural counterparts. Improving the catalytic activity and expanding the category of nanozymes are prerequisites to complement or even supersede enzymes. However, the development of hydrolytic nanozymes is still challenged by diverse hydrolytic substrates and following complicated mechanisms. Here, two strategies are informed by data to screen and predict catalytic active sites of MOF (metal–organic framework) based hydrolytic nanozymes: (1) to increase the intrinsic activity by finely tuned Lewis acidity of the metal clusters; (2) to improve the density of active sites by shortening the length of ligands. Finally, as-obtained Ce-FMA-MOF-based hydrolytic nanozyme is capable of cleaving phosphate bonds, amide bonds, glycosidic bonds, and even their mixture, biofilms. This work provides a rational methodology to design hydrolytic nanozyme, enriches the diversity of nanozymes, and potentially sheds light on future evolution of enzyme engineering.

Date: 2022
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DOI: 10.1038/s41467-022-28344-2

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