Versioning biological cells for trustworthy cell engineering

Jonathan Tellechea-Luzardo, Leanne Hobbs, Elena Velázquez, Lenka Pelechova, Simon Woods, Víctor Lorenzo and Natalio Krasnogor ()
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Jonathan Tellechea-Luzardo: Newcastle University
Leanne Hobbs: Newcastle University
Elena Velázquez: Systems and Synthetic Biology Department, Centro Nacional de Biotecnología (CNB-CSIC)
Lenka Pelechova: Newcastle University
Simon Woods: Newcastle University
Víctor Lorenzo: Systems and Synthetic Biology Department, Centro Nacional de Biotecnología (CNB-CSIC)
Natalio Krasnogor: Newcastle University

Nature Communications, 2022, vol. 13, issue 1, 1-12

Abstract: Abstract “Full-stack” biotechnology platforms for cell line (re)programming are on the horizon, thanks mostly to (a) advances in gene synthesis and editing techniques as well as (b) the growing integration of life science research with informatics, the internet of things and automation. These emerging platforms will accelerate the production and consumption of biological products. Hence, traceability, transparency, and—ultimately—trustworthiness is required from cradle to grave for engineered cell lines and their engineering processes. Here we report a cloud-based version control system for biotechnology that (a) keeps track and organizes the digital data produced during cell engineering and (b) molecularly links that data to the associated living samples. Barcoding protocols, based on standard genetic engineering methods, to molecularly link to the cloud-based version control system six species, including gram-negative and gram-positive bacteria as well as eukaryote cells, are shown. We argue that version control for cell engineering marks a significant step toward more open, reproducible, easier to trace and share, and more trustworthy engineering biology.

Date: 2022
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DOI: 10.1038/s41467-022-28350-4

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