Placental genomics mediates genetic associations with complex health traits and disease

Arjun Bhattacharya (), Anastasia N. Freedman, Vennela Avula, Rebeca Harris, Weifang Liu, Calvin Pan, Aldons J. Lusis, Robert M. Joseph, Lisa Smeester, Hadley J. Hartwell, Karl C. K. Kuban, Carmen J. Marsit, Yun Li, T. Michael O’Shea, Rebecca C. Fry () and Hudson P. Santos ()
Additional contact information
Arjun Bhattacharya: University of California
Anastasia N. Freedman: University of North Carolina
Vennela Avula: University of North Carolina
Rebeca Harris: University of North Carolina
Weifang Liu: University of North Carolina
Calvin Pan: University of California
Aldons J. Lusis: University of California
Robert M. Joseph: Boston University School of Medicine
Lisa Smeester: University of North Carolina
Hadley J. Hartwell: University of North Carolina
Karl C. K. Kuban: Boston University Medical Center
Carmen J. Marsit: Rollins School of Public Health Emory University
Yun Li: University of North Carolina
T. Michael O’Shea: University of North Carolina
Rebecca C. Fry: University of North Carolina
Hudson P. Santos: University of North Carolina

Nature Communications, 2022, vol. 13, issue 1, 1-15

Abstract: Abstract As the master regulator in utero, the placenta is core to the Developmental Origins of Health and Disease (DOHaD) hypothesis but is historically understudied. To identify placental gene-trait associations (GTAs) across the life course, we perform distal mediator-enriched transcriptome-wide association studies (TWAS) for 40 traits, integrating placental multi-omics from the Extremely Low Gestational Age Newborn Study. At $$P \;

Date: 2022
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DOI: 10.1038/s41467-022-28365-x

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