CMTr cap-adjacent 2′-O-ribose mRNA methyltransferases are required for reward learning and mRNA localization to synapses

Irmgard U. Haussmann, Yanying Wu, Mohanakarthik P. Nallasivan, Nathan Archer, Zsuzsanna Bodi, Daniel Hebenstreit, Scott Waddell, Rupert Fray and Matthias Soller ()
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Irmgard U. Haussmann: University of Birmingham
Yanying Wu: The University of Oxford
Mohanakarthik P. Nallasivan: University of Birmingham
Nathan Archer: University of Nottingham
Zsuzsanna Bodi: University of Nottingham
Daniel Hebenstreit: University of Warwick
Scott Waddell: The University of Oxford
Rupert Fray: University of Nottingham
Matthias Soller: University of Birmingham

Nature Communications, 2022, vol. 13, issue 1, 1-13

Abstract: Abstract Cap-adjacent nucleotides of animal, protist and viral mRNAs can be O-methylated at the 2‘ position of the ribose (cOMe). The functions of cOMe in animals, however, remain largely unknown. Here we show that the two cap methyltransferases (CMTr1 and CMTr2) of Drosophila can methylate the ribose of the first nucleotide in mRNA. Double-mutant flies lack cOMe but are viable. Consistent with prominent neuronal expression, they have a reward learning defect that can be rescued by conditional expression in mushroom body neurons before training. Among CMTr targets are cell adhesion and signaling molecules. Many are relevant for learning, and are also targets of Fragile X Mental Retardation Protein (FMRP). Like FMRP, cOMe is required for localization of untranslated mRNAs to synapses and enhances binding of the cap binding complex in the nucleus. Hence, our study reveals a mechanism to co-transcriptionally prime mRNAs by cOMe for localized protein synthesis at synapses.

Date: 2022
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DOI: 10.1038/s41467-022-28549-5

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