Disuse-associated loss of the protease LONP1 in muscle impairs mitochondrial function and causes reduced skeletal muscle mass and strength

Zhisheng Xu, Tingting Fu, Qiqi Guo, Danxia Zhou, Wanping Sun, Zheng Zhou, Xinyi Chen, Jingzi Zhang, Lin Liu, Liwei Xiao, Yujing Yin, Yuhuan Jia, Erkai Pang, Yuncong Chen, Xin Pan, Lei Fang, Min-sheng Zhu, Wenyong Fei, Bin Lu and Zhenji Gan ()
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Zhisheng Xu: Nanjing University Medical School, Nanjing University
Tingting Fu: Nanjing University Medical School, Nanjing University
Qiqi Guo: Nanjing University Medical School, Nanjing University
Danxia Zhou: Nanjing University Medical School, Nanjing University
Wanping Sun: Nanjing University Medical School, Nanjing University
Zheng Zhou: Nanjing University Medical School, Nanjing University
Xinyi Chen: Nanjing University Medical School, Nanjing University
Jingzi Zhang: Medical School of Nanjing University
Lin Liu: Nanjing University Medical School, Nanjing University
Liwei Xiao: Nanjing University Medical School, Nanjing University
Yujing Yin: Nanjing University Medical School, Nanjing University
Yuhuan Jia: Nanjing University Medical School, Nanjing University
Erkai Pang: Yangzhou University
Yuncong Chen: Nanjing University
Xin Pan: National Center of Biomedical Analysis
Lei Fang: Medical School of Nanjing University
Min-sheng Zhu: Nanjing University
Wenyong Fei: Yangzhou University
Bin Lu: University of South China
Zhenji Gan: Nanjing University Medical School, Nanjing University

Nature Communications, 2022, vol. 13, issue 1, 1-20

Abstract: Abstract Mitochondrial proteolysis is an evolutionarily conserved quality-control mechanism to maintain proper mitochondrial integrity and function. However, the physiological relevance of stress-induced impaired mitochondrial protein quality remains unclear. Here, we demonstrate that LONP1, a major mitochondrial protease resides in the matrix, plays a role in controlling mitochondrial function as well as skeletal muscle mass and strength in response to muscle disuse. In humans and mice, disuse-related muscle loss is associated with decreased mitochondrial LONP1 protein. Skeletal muscle-specific ablation of LONP1 in mice resulted in impaired mitochondrial protein turnover, leading to mitochondrial dysfunction. This caused reduced muscle fiber size and strength. Mechanistically, aberrant accumulation of mitochondrial-retained protein in muscle upon loss of LONP1 induces the activation of autophagy-lysosome degradation program of muscle loss. Overexpressing a mitochondrial-retained mutant ornithine transcarbamylase (ΔOTC), a known protein degraded by LONP1, in skeletal muscle induces mitochondrial dysfunction, autophagy activation, and cause muscle loss and weakness. Thus, these findings reveal a role of LONP1-dependent mitochondrial protein quality-control in safeguarding mitochondrial function and preserving skeletal muscle mass and strength, and unravel a link between mitochondrial protein quality and muscle mass maintenance during muscle disuse.

Date: 2022
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DOI: 10.1038/s41467-022-28557-5

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