The insect somatostatin pathway gates vitellogenesis progression during reproductive maturation and the post-mating response

Chen Zhang, Anmo J. Kim, Crisalesandra Rivera-Perez, Fernando G. Noriega and Young-Joon Kim ()
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Chen Zhang: School of Life Sciences, Gwangju Institute of Science and Technology (GIST)
Anmo J. Kim: Hanyang University
Crisalesandra Rivera-Perez: Department of Fisheries Ecology, Consejo Nacional de Ciencia y Tecnología, Centro de Investigaciones Biológicas del Noroeste
Fernando G. Noriega: Florida International University
Young-Joon Kim: School of Life Sciences, Gwangju Institute of Science and Technology (GIST)

Nature Communications, 2022, vol. 13, issue 1, 1-15

Abstract: Abstract Vitellogenesis (yolk accumulation) begins upon eclosion and continues through the process of sexual maturation. Upon reaching sexual maturity, vitellogenesis is placed on hold until it is induced again by mating. However, the mechanisms that gate vitellogenesis in response to developmental and reproductive signals remain unclear. Here, we have identified the neuropeptide allatostatin-C (AstC)-producing neurons that gate both the initiation of vitellogenesis that occurs post-eclosion and its re-initiation post-mating. During sexual maturation, the AstC neurons receive excitatory inputs from Sex Peptide Abdominal Ganglion (SAG) neurons. In mature virgin females, high sustained activity of SAG neurons shuts off vitellogenesis via continuous activation of the AstC neurons. Upon mating, however, Sex Peptide inhibits SAG neurons, leading to deactivation of the AstC neurons. As a result, this permits both JH biosynthesis and the progression of vitellogenesis in mated females. Our work has uncovered a central neural circuit that gates the progression of oogenesis.

Date: 2022
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DOI: 10.1038/s41467-022-28592-2

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